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Literature summary extracted from

  • Novaroli, L.; Reist, M.; Favre, E.; Carotti, A.; Catto, M.; Carrupt, P.A.
    Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening (2005), Bioorg. Med. Chem., 13, 6212-6217.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 2-oxo-2H-chromen-7-yl benzenesulfonate
-
 Homo sapiens
1.4.3.4 2-{[(3,4-dimethyl-2-oxo-2H-chromen-7-yl)oxy]methyl}benzonitrile
-
 Homo sapiens
1.4.3.4 3,4-dimethyl-2-oxo-2H-chromen-7-yl 4-methoxybenzenesulfonate
-
 Homo sapiens
1.4.3.4 3,4-dimethyl-2-oxo-2H-chromen-7-yl benzenesulfonate
-
 Homo sapiens
1.4.3.4 3,4-dimethyl-7-(2-oxo-2-phenylethoxy)-2H-chromen-2-one
-
 Homo sapiens
1.4.3.4 3,4-dimethyl-7-[(3-nitrobenzyl)oxy]-2H-chromen-2-one
-
 Homo sapiens
1.4.3.4 3,4-dimethyl-7-[(pentafluorobenzyl)oxy]-2H-chromen-2-one
-
 Homo sapiens
1.4.3.4 3,4-dimethyl-7-{[3-(trifluoromethoxy)benzyl]oxy}-2H-chromen-2-one
-
 Homo sapiens
1.4.3.4 3-(2-chlorophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
 Homo sapiens
1.4.3.4 3-(2-naphthyl)-5H-indeno[1,2-c]pyridazin-5-one
-
 Homo sapiens
1.4.3.4 3-(2-nitrophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
 Homo sapiens
1.4.3.4 3-(3-bromophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
 Homo sapiens
1.4.3.4 3-(3-fluorophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
 Homo sapiens
1.4.3.4 3-(3-methoxyphenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
 Homo sapiens
1.4.3.4 3-(4-bromophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
 Homo sapiens
1.4.3.4 3-(4-methoxyphenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
 Homo sapiens
1.4.3.4 3-(4-nitrophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
 Homo sapiens
1.4.3.4 3-(5-oxo-5H-indeno[1,2-c]pyridazin-3-yl)benzonitrile
-
 Homo sapiens
1.4.3.4 3-(benzyloxy)-6a,10a-dihydro-6H-benzo[c]chromen-6-one
-
 Homo sapiens
1.4.3.4 3-benzyl-5H-indeno[1,2-c]pyridazin-5-one
-
 Homo sapiens
1.4.3.4 3-[(E)-2-phenylvinyl]-5H-indeno[1,2-c]pyridazin-5-one
-
 Homo sapiens
1.4.3.4 3-[4-(trifluoromethyl)phenyl]-5H-indeno[1,2-c]pyridazin-5-one
-
 Homo sapiens
1.4.3.4 3-{[(3,4-dimethyl-2-oxo-2H-chromen-7-yl)oxy]methyl}benzonitrile
-
 Homo sapiens
1.4.3.4 7-(anilinomethyl)-2H-chromen-2-one
-
 Homo sapiens
1.4.3.4 7-(benzylamino)-3,4-dimethyl-2H-chromen-2-one
-
 Homo sapiens
1.4.3.4 7-(benzyloxy)-2H-chromen-2-one
-
 Homo sapiens
1.4.3.4 7-(benzyloxy)-3,4-dimethyl-2H-chromen-2-one
-
 Homo sapiens
1.4.3.4 7-(benzyloxy)-4-methyl-2H-chromen-2-one
-
 Homo sapiens
1.4.3.4 7-(benzyloxy)-4-phenyl-2H-chromen-2-one
-
 Homo sapiens
1.4.3.4 additional information recombinant enzyme obtained from a Baculovirus expression system is validated as convenient enzyme source for MAO B inhibitor screening Homo sapiens
1.4.3.4 N-(3,4-dimethyl-2-oxo-2H-chromen-7-yl)benzamide
-
 Homo sapiens
1.4.3.4 N-(3-{[(3,4-dimethyl-2-oxo-2H-chromen-7-yl)oxy]methyl}phenyl)acetamide
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 0.03
-
 kynuramine
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens P27338
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 kynuramine + H2O + O2
-
 Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO B
-
 Homo sapiens
1.4.3.4 monoamine oxidase B
-
 Homo sapiens