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Literature summary extracted from

  • Yamazaki, K.; Kaneko, Y.; Suwa, K.; Ebara, S.; Nakazawa, K.; Yasuno, K.
    Synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase based on the benzothiazole structure (2005), Bioorg. Med. Chem., 13, 2509-2522.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.97 expression in Escherichia coli Homo sapiens
2.3.1.97 expression in Escherichia coli Candida albicans

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.97 (1R,3S)-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide IC50: 0.00000049 mM Candida albicans
2.3.1.97 (1R,3S)-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclopentanecarboxamide IC50: 0.000015 mM Candida albicans
2.3.1.97 (1S,3R)-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide IC50: above 0.00001 mM Candida albicans
2.3.1.97 (1S,3R)-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclopentanecarboxamide IC50: 0.000011mM Candida albicans
2.3.1.97 2-(acetylamino)-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide IC50: above 0.01 mM Candida albicans
2.3.1.97 2-(benzylamino)-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide IC50: above 0.01 mM Candida albicans
2.3.1.97 2-amino-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide IC50: above 0.01 mM Candida albicans
2.3.1.97 2-[(2-methylpropanoyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide IC50: 0.000046 mM Candida albicans
2.3.1.97 2-[(2-methylpropanoyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide 14% inhibition at 0.01 mM Homo sapiens
2.3.1.97 2-[(cyclobutylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide IC50: 0.000028 mM Candida albicans
2.3.1.97 2-[(cyclobutylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide 22% inhibition at 0.01 mM Homo sapiens
2.3.1.97 2-[(cyclohexanecarbonyl)amino]-N-[(2-naphthylmethyl)amino]ethyl-benzothiazole-6-carboxamide IC50: 0.0000344 mM Candida albicans
2.3.1.97 2-[(cyclohexanecarbonyl)amino]-N-[(2-naphthylmethyl)amino]ethyl-benzothiazole-6-carboxamide 49% inhibition at 0.01 mM Homo sapiens
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-1-methyl-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1H-benzimidazole-5-carboxamide IC50: above 0.1 mM Candida albicans
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-1-methyl-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1H-benzimidazole-6-carboxamide IC50: above 0.1 mM Candida albicans
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-N-(3-[[(naphthalen-2-ylmethyl)amino]methyl]benzyl)-1,3-benzothiazole-6-carboxamide IC50: 0.0019 mM Candida albicans
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-N-(4-[[(naphthalen-2-ylmethyl)amino]methyl]benzyl)-1,3-benzothiazole-6-carboxamide IC50: above 0.1 mM Candida albicans
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-5-carboxamide IC50: 0.0068 mM Candida albicans
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-7-carboxamide IC50: 0.001 mM Candida albicans
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzoxazole-5-carboxamide IC50: 0.0011 mM Candida albicans
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzoxazole-6-carboxamide IC50: 0.00029 mM Candida albicans
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-N-[3-[(naphthalen-2-ylmethyl)amino]propyl]-1,3-benzothiazole-6-carboxamide IC50: 0.00011 mM Candida albicans
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-N-[3-[(naphthalen-2-ylmethyl)amino]propyl]-1,3-benzothiazole-6-carboxamide 61% inhibition at 0.01 mM Homo sapiens
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-N-[4-[(naphthalen-2-ylmethyl)amino]butyl]-1,3-benzothiazole-6-carboxamide IC50: 0.000074 mM Candida albicans
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-N-[4-[(naphthalen-2-ylmethyl)amino]butyl]-1,3-benzothiazole-6-carboxamide 43% inhibition at 0.01 mM Homo sapiens
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-N-[5-[(naphthalen-2-ylmethyl)amino]pentyl]-1,3-benzothiazole-6-carboxamide IC50: 0.0003 mM Candida albicans
2.3.1.97 2-[(cyclohexylcarbonyl)amino]-N-[5-[(naphthalen-2-ylmethyl)amino]pentyl]-1,3-benzothiazole-6-carboxamide 46% inhibition at 0.01 mM Homo sapiens
2.3.1.97 2-[(cyclohexylmethyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide IC50: above 0.001 mM Candida albicans
2.3.1.97 2-[(cyclopentylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide IC50: 0.000023 mM Candida albicans
2.3.1.97 2-[(cyclopentylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide 32% inhibition at 0.01 mM Homo sapiens
2.3.1.97 2-[[(2,5-dimethoxyphenyl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide IC50: 0.00031 mM Candida albicans
2.3.1.97 2-[[(2,5-dimethoxyphenyl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide 71% inhibition at 0.01 mM Homo sapiens
2.3.1.97 2-[[(2-chloropyridin-3-yl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide IC50: above 0.01 mM Candida albicans
2.3.1.97 2-[[(2-chloropyridin-3-yl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide 16% inhibition at 0.01 mM Homo sapiens
2.3.1.97 2-[[(3,4-dichlorophenyl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide IC50: above 0.01 mM Candida albicans
2.3.1.97 2-[[(3,4-dichlorophenyl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide 22% inhibition at 0.01 mM Homo sapiens
2.3.1.97 2-[[(4-chlorophenyl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide IC50: above 0.01 mM Candida albicans
2.3.1.97 2-[[(4-chlorophenyl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide 8% inhibition at 0.01 mM Homo sapiens
2.3.1.97 N-(6-[[N-(biphenyl-4-ylmethyl)-b-alanyl]amino]-1,3-benzothiazol-2-yl)cyclopentanecarboxamide IC50: 0.00016 mM Candida albicans
2.3.1.97 N-(6-[[N-(naphthalen-2-ylmethyl)-b-alanyl]amino]-1,3-benzothiazol-2-yl)cyclohexanecarboxamide IC50: 0.00018 mM Candida albicans
2.3.1.97 N-(6-[[N-(naphthalen-2-ylmethyl)-b-alanyl]amino]-1,3-benzothiazol-2-yl)cyclohexanecarboxamide 32% inhibition at 0.01 mM Homo sapiens
2.3.1.97 N-(6-[[N-(naphthalen-2-ylmethyl)glycyl]amino]-1,3-benzothiazol-2-yl)cyclohexanecarboxamide IC50: 0.0023 mM Candida albicans
2.3.1.97 N-(6-[[N-(naphthalen-2-ylmethyl)glycyl]amino]-1,3-benzothiazol-2-yl)cyclohexanecarboxamide 8% inhibition at 0.01 mM Homo sapiens
2.3.1.97 N-[2-[(2-methylpropanoyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide IC50: 0.0000033 mM Candida albicans
2.3.1.97 N-[2-[(cyclobutylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide IC50: 0.0000023 mM Candida albicans
2.3.1.97 N-[2-[(cyclohexylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide IC50: 0.0000081 mM Candida albicans
2.3.1.97 N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide IC50: 0.0000012 mM Candida albicans
2.3.1.97 N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[[(4-phenylcyclohexa-1,5-dien-1-yl)methyl]amino]cyclohexanecarboxamide IC50: 0.00013 mM Candida albicans
2.3.1.97 N-[2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide IC50: 0.0000024 mM Candida albicans
2.3.1.97 N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide IC50: above 0.01 mM Candida albicans
2.3.1.97 N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-(propanoylamino)-1,3-benzothiazole-6-carboxamide IC50: 0.00013 mM Candida albicans
2.3.1.97 N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-(propanoylamino)-1,3-benzothiazole-6-carboxamide 4% inhibition at 0.01 mM Homo sapiens
2.3.1.97 N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-([[4-(trifluoromethyl)phenyl]carbonyl]amino)-1,3-benzothiazole-6-carboxamide IC50: above 0.01 mM Candida albicans
2.3.1.97 N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-([[4-(trifluoromethyl)phenyl]carbonyl]amino)-1,3-benzothiazole-6-carboxamide 1% inhibition at 0.01 mM Homo sapiens
2.3.1.97 N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(phenylcarbonyl)amino]-1,3-benzothiazole-6-carboxamide IC50: 0.00016 mM Candida albicans
2.3.1.97 N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(phenylcarbonyl)amino]-1,3-benzothiazole-6-carboxamide 32% inhibition at 0.01 mM Homo sapiens
2.3.1.97 N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(pyrazin-2-ylcarbonyl)amino]-1,3-benzothiazole-6-carboxamide IC50: 0.00073 mM Candida albicans
2.3.1.97 N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(pyrazin-2-ylcarbonyl)amino]-1,3-benzothiazole-6-carboxamide 11% inhibition at 0.01 mM Homo sapiens
2.3.1.97 N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(pyridin-2-ylcarbonyl)amino]-1,3-benzothiazole-6-carboxamide IC50: above 0.01 mM Candida albicans
2.3.1.97 N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(pyridin-2-ylcarbonyl)amino]-1,3-benzothiazole-6-carboxamide 37% inhibition at 0.01 mM Homo sapiens
2.3.1.97 N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(pyridin-2-ylmethyl)amino]-1,3-benzothiazole-6-carboxamide IC50: above 0.01 mM Candida albicans
2.3.1.97 N-[6-([3-[(naphthalen-2-ylmethyl)amino]azetidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide IC50: 0.000065 mM Candida albicans
2.3.1.97 N-[6-([3-[(naphthalen-2-ylmethyl)amino]azetidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide 14% inhibition at 0.01 mM Homo sapiens
2.3.1.97 N-[6-([3-[(naphthalen-2-ylmethyl)amino]piperidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide IC50: 0.00021 mM Candida albicans
2.3.1.97 N-[6-([3-[(naphthalen-2-ylmethyl)amino]piperidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide 27% inhibition at 0.01 mM Homo sapiens
2.3.1.97 N-[6-([3-[(naphthalen-2-ylmethyl)amino]pyrrolidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide IC50: 0.00019 mM Candida albicans
2.3.1.97 N-[6-([3-[(naphthalen-2-ylmethyl)amino]pyrrolidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide 36% inhibition at 0.01 mM Homo sapiens
2.3.1.97 N-[6-([4-[(naphthalen-2-ylmethyl)amino]butanoyl]amino)-1,3-benzothiazol-2-yl]cyclopentanecarboxamide IC50: 0.000015 mM Candida albicans
2.3.1.97 N-[6-([4-[(naphthalen-2-ylmethyl)amino]piperidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide IC50: 0.0005 mM Candida albicans
2.3.1.97 N-[6-([4-[(naphthalen-2-ylmethyl)amino]piperidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide 27% inhibition at 0.01 mM Homo sapiens
2.3.1.97 N-[6-[(4-[[(naphthalen-2-ylmethyl)amino]methyl]piperidin-1-yl)carbonyl]-1,3-benzothiazol-2-yl]cyclohexanecarboxamide IC50: 0.000026 mM Candida albicans
2.3.1.97 N-[6-[(4-[[(naphthalen-2-ylmethyl)amino]methyl]piperidin-1-yl)carbonyl]-1,3-benzothiazol-2-yl]cyclohexanecarboxamide 32% inhibition at 0.01 mM Homo sapiens
2.3.1.97 tert-butyl [6-([2-[(naphthalen-2-ylmethyl)amino]ethyl]carbamoyl)-1,3-benzothiazol-2-yl]carbamate IC50: above 0.01 mM Candida albicans
2.3.1.97 trans-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide IC50: 0.000034 mM Candida albicans

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.97 Candida albicans P30418
-
-
2.3.1.97 Homo sapiens P30419
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.97
-
 Homo sapiens
2.3.1.97
-
 Candida albicans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.97 myristoyl-CoA + GLTISKLFRR
-
 Candida albicans ?
-
 ?
2.3.1.97 myristoyl-CoA + GNAASARR
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.97 CaNMT
-
 Candida albicans
2.3.1.97 HsNMT1
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.97 0.00000049
-
 IC50: 0.00000049 mM Candida albicans (1R,3S)-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
2.3.1.97 0.0000012
-
 IC50: 0.0000012 mM Candida albicans N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
2.3.1.97 0.0000023
-
 IC50: 0.0000023 mM Candida albicans N-[2-[(cyclobutylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
2.3.1.97 0.0000024
-
 IC50: 0.0000024 mM Candida albicans N-[2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
2.3.1.97 0.0000033
-
 IC50: 0.0000033 mM Candida albicans N-[2-[(2-methylpropanoyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
2.3.1.97 0.0000081
-
 IC50: 0.0000081 mM Candida albicans N-[2-[(cyclohexylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
2.3.1.97 0.00001
-
 IC50: above 0.00001 mM Candida albicans (1S,3R)-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
2.3.1.97 0.000011
-
 IC50: 0.000011mM Candida albicans (1S,3R)-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclopentanecarboxamide
2.3.1.97 0.000015
-
 IC50: 0.000015 mM Candida albicans N-[6-([4-[(naphthalen-2-ylmethyl)amino]butanoyl]amino)-1,3-benzothiazol-2-yl]cyclopentanecarboxamide
2.3.1.97 0.000015
-
 IC50: 0.000015 mM Candida albicans (1R,3S)-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclopentanecarboxamide
2.3.1.97 0.000023
-
 IC50: 0.000023 mM Candida albicans 2-[(cyclopentylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.000026
-
 IC50: 0.000026 mM Candida albicans N-[6-[(4-[[(naphthalen-2-ylmethyl)amino]methyl]piperidin-1-yl)carbonyl]-1,3-benzothiazol-2-yl]cyclohexanecarboxamide
2.3.1.97 0.000028
-
 IC50: 0.000028 mM Candida albicans 2-[(cyclobutylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.000034
-
 IC50: 0.000034 mM Candida albicans trans-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
2.3.1.97 0.0000344
-
 IC50: 0.0000344 mM Candida albicans 2-[(cyclohexanecarbonyl)amino]-N-[(2-naphthylmethyl)amino]ethyl-benzothiazole-6-carboxamide
2.3.1.97 0.000046
-
 IC50: 0.000046 mM Candida albicans 2-[(2-methylpropanoyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.000065
-
 IC50: 0.000065 mM Candida albicans N-[6-([3-[(naphthalen-2-ylmethyl)amino]azetidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide
2.3.1.97 0.000074
-
 IC50: 0.000074 mM Candida albicans 2-[(cyclohexylcarbonyl)amino]-N-[4-[(naphthalen-2-ylmethyl)amino]butyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.00011
-
 IC50: 0.00011 mM Candida albicans 2-[(cyclohexylcarbonyl)amino]-N-[3-[(naphthalen-2-ylmethyl)amino]propyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.00013
-
 IC50: 0.00013 mM Candida albicans N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-(propanoylamino)-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.00013
-
 IC50: 0.00013 mM Candida albicans N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[[(4-phenylcyclohexa-1,5-dien-1-yl)methyl]amino]cyclohexanecarboxamide
2.3.1.97 0.00016
-
 IC50: 0.00016 mM Candida albicans N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(phenylcarbonyl)amino]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.00016
-
 IC50: 0.00016 mM Candida albicans N-(6-[[N-(biphenyl-4-ylmethyl)-b-alanyl]amino]-1,3-benzothiazol-2-yl)cyclopentanecarboxamide
2.3.1.97 0.00018
-
 IC50: 0.00018 mM Candida albicans N-(6-[[N-(naphthalen-2-ylmethyl)-b-alanyl]amino]-1,3-benzothiazol-2-yl)cyclohexanecarboxamide
2.3.1.97 0.00019
-
 IC50: 0.00019 mM Candida albicans N-[6-([3-[(naphthalen-2-ylmethyl)amino]pyrrolidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide
2.3.1.97 0.00021
-
 IC50: 0.00021 mM Candida albicans N-[6-([3-[(naphthalen-2-ylmethyl)amino]piperidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide
2.3.1.97 0.00029
-
 IC50: 0.00029 mM Candida albicans 2-[(cyclohexylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzoxazole-6-carboxamide
2.3.1.97 0.0003
-
 IC50: 0.0003 mM Candida albicans 2-[(cyclohexylcarbonyl)amino]-N-[5-[(naphthalen-2-ylmethyl)amino]pentyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.00031
-
 IC50: 0.00031 mM Candida albicans 2-[[(2,5-dimethoxyphenyl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.0005
-
 IC50: 0.0005 mM Candida albicans N-[6-([4-[(naphthalen-2-ylmethyl)amino]piperidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide
2.3.1.97 0.00073
-
 IC50: 0.00073 mM Candida albicans N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(pyrazin-2-ylcarbonyl)amino]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.001
-
 IC50: 0.001 mM Candida albicans 2-[(cyclohexylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-7-carboxamide
2.3.1.97 0.001
-
 IC50: above 0.001 mM Candida albicans 2-[(cyclohexylmethyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.0011
-
 IC50: 0.0011 mM Candida albicans 2-[(cyclohexylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzoxazole-5-carboxamide
2.3.1.97 0.0019
-
 IC50: 0.0019 mM Candida albicans 2-[(cyclohexylcarbonyl)amino]-N-(3-[[(naphthalen-2-ylmethyl)amino]methyl]benzyl)-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.0023
-
 IC50: 0.0023 mM Candida albicans N-(6-[[N-(naphthalen-2-ylmethyl)glycyl]amino]-1,3-benzothiazol-2-yl)cyclohexanecarboxamide
2.3.1.97 0.0068
-
 IC50: 0.0068 mM Candida albicans 2-[(cyclohexylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-5-carboxamide
2.3.1.97 0.01
-
 IC50: above 0.01 mM Candida albicans N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(pyridin-2-ylcarbonyl)amino]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.01
-
 IC50: above 0.01 mM Candida albicans 2-[[(2-chloropyridin-3-yl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.01
-
 IC50: above 0.01 mM Candida albicans 2-[[(4-chlorophenyl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.01
-
 IC50: above 0.01 mM Candida albicans 2-[[(3,4-dichlorophenyl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.01
-
 IC50: above 0.01 mM Candida albicans N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-([[4-(trifluoromethyl)phenyl]carbonyl]amino)-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.01
-
 IC50: above 0.01 mM Candida albicans N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.01
-
 IC50: above 0.01 mM Candida albicans 2-amino-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.01
-
 IC50: above 0.01 mM Candida albicans 2-(benzylamino)-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.01
-
 IC50: above 0.01 mM Candida albicans N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(pyridin-2-ylmethyl)amino]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.01
-
 IC50: above 0.01 mM Candida albicans tert-butyl [6-([2-[(naphthalen-2-ylmethyl)amino]ethyl]carbamoyl)-1,3-benzothiazol-2-yl]carbamate
2.3.1.97 0.01
-
 IC50: above 0.01 mM Candida albicans 2-(acetylamino)-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.1
-
 IC50: above 0.1 mM Candida albicans 2-[(cyclohexylcarbonyl)amino]-N-(4-[[(naphthalen-2-ylmethyl)amino]methyl]benzyl)-1,3-benzothiazole-6-carboxamide
2.3.1.97 0.1
-
 IC50: above 0.1 mM Candida albicans 2-[(cyclohexylcarbonyl)amino]-1-methyl-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1H-benzimidazole-5-carboxamide
2.3.1.97 0.1
-
 IC50: above 0.1 mM Candida albicans 2-[(cyclohexylcarbonyl)amino]-1-methyl-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1H-benzimidazole-6-carboxamide