Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Park, Y.D.; Lee, W.S.; An, S.; Jeong, T.S.
    Human acyl-CoA: cholesterol acyltransferase inhibitory activities of aliphatic acid amides from Zanthoxylum piperitum DC (2007), Biol. Pharm. Bull., 30, 205-207.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.26 the baculovirus system is used Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 2-[(2E,6Z,8E,10E)-dodeca-2,6,8,10-tetraenoylamino]-1,1-dimethylethyl acetate IC50: 0.0281 mM; IC50: 0.0875 mM Homo sapiens
2.3.1.26 beta-sanshool extracted from Zanthoxylum piperitum DC; IC50: 0.012 mM; IC50: 0.039 mM Homo sapiens
2.3.1.26 beta-sanshool acetate semi-synthetic compound Homo sapiens
2.3.1.26 gamma-sanshool extracted from Zanthoxylum piperitum DC; IC50: 0.0797 mM; IC50: 0.0826 mM Homo sapiens
2.3.1.26 hydroxy-beta-sanshool low inhibition; low inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol Homo sapiens
-
 CoA + cholesterol ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Homo sapiens
-
-
-
2.3.1.26 Homo sapiens O75908
-
-
2.3.1.26 Homo sapiens P35610
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.26 microsomal fractions of Hi5 cells containing baculovirally expressed hACAT-1 are prepared and used as the source for the enzyme Homo sapiens
2.3.1.26 microsomal fractions of Hi5 cells containing baculovirally expressed hACAT-2 are prepared and used as the source for the enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol ester
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol ACAT activity assay Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.26 ACAT-1
-
 Homo sapiens
2.3.1.26 ACAT-2
-
 Homo sapiens
2.3.1.26 acyl-CoA: cholesterol acyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.26 37
-
 activity assay Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.26 7.4
-
 activity assay Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.26 0.012
-
-
 Homo sapiens beta-sanshool
2.3.1.26 0.012
-
 IC50: 0.012 mM Homo sapiens beta-sanshool
2.3.1.26 0.0281
-
-
 Homo sapiens beta-sanshool acetate
2.3.1.26 0.0281
-
 IC50: 0.0281 mM Homo sapiens 2-[(2E,6Z,8E,10E)-dodeca-2,6,8,10-tetraenoylamino]-1,1-dimethylethyl acetate
2.3.1.26 0.039
-
-
 Homo sapiens beta-sanshool
2.3.1.26 0.039
-
 IC50: 0.039 mM Homo sapiens beta-sanshool
2.3.1.26 0.0797
-
-
 Homo sapiens gamma-sanshool
2.3.1.26 0.0797
-
 IC50: 0.0797 mM Homo sapiens gamma-sanshool
2.3.1.26 0.0826
-
-
 Homo sapiens gamma-sanshool
2.3.1.26 0.0826
-
 IC50: 0.0826 mM Homo sapiens gamma-sanshool
2.3.1.26 0.0875
-
-
 Homo sapiens beta-sanshool acetate
2.3.1.26 0.0875
-
 IC50: 0.0875 mM Homo sapiens 2-[(2E,6Z,8E,10E)-dodeca-2,6,8,10-tetraenoylamino]-1,1-dimethylethyl acetate