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Literature summary extracted from

  • Ochiai, Y.; Itoh, K.; Sakurai, E.; Adachi, M.; Tanaka, Y.
    Substrate selectivity of monoamine oxidase A, monoamine oxidase B, diamine oxidase, and semicarbazide-sensitive amine oxidase in COS-1 expression systems (2006), Biol. Pharm. Bull., 29, 2362-2366.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.4 expressed in COS-1 cells Rattus norvegicus
1.4.3.4 expression in Cos-1 cells Rattus norvegicus
1.4.3.21 expressed in COS-1 cells Rattus norvegicus
1.4.3.22 expressed in COS-1 cells Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 Clorgyline
-
 Rattus norvegicus
1.4.3.4 Deprenyl
-
 Rattus norvegicus
1.4.3.4 Semicarbazide
-
 Rattus norvegicus
1.4.3.21 additional information clorgyline and deprenyl do not significantly inhibit the activities Rattus norvegicus
1.4.3.21 Semicarbazide causes significant decreases in the oxidative deamination activity of four among the five substrates catalyzed by SSAO Rattus norvegicus
1.4.3.22 additional information clorgyline and deprenyl do not decrease DAO activity Rattus norvegicus
1.4.3.22 Semicarbazide very strong inhibition Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Rattus norvegicus P19643
-
-
1.4.3.4 Rattus norvegicus P19643 nine-week-old male Wistar rats
-
1.4.3.4 Rattus norvegicus P21396
-
-
1.4.3.4 Rattus norvegicus P21396 nine-week-old male Wistar rats
-
1.4.3.21 Rattus norvegicus O08590 nine-week-old male Wistar rats
-
1.4.3.22 Rattus norvegicus P36633 nine-week-old male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.4 0.00004
-
 substrate histamine, at high substrate concentration Rattus norvegicus
1.4.3.4 0.00009
-
 substrate beta-phenylethylamine, at low substrate concentration Rattus norvegicus
1.4.3.4 0.00011
-
 substrate tyramine, at low substrate concentration Rattus norvegicus
1.4.3.4 0.00018
-
 substrate tyramine, at low substrate concentration Rattus norvegicus
1.4.3.4 0.00019
-
 substrate benzylamine, at low substrate concentration Rattus norvegicus
1.4.3.4 0.00021
-
 substrate beta-phenylethylamine, at low substrate concentration Rattus norvegicus
1.4.3.4 0.0003
-
 substrate benzylamine, at low substrate concentration Rattus norvegicus
1.4.3.4 0.00036
-
 substrate 1-methylhistamine, at high substrate concentration Rattus norvegicus
1.4.3.4 0.00054
-
 substrate benzylamine, at high substrate concentration Rattus norvegicus
1.4.3.4 0.00054
-
 substrate histamine, at high substrate concentration Rattus norvegicus
1.4.3.4 0.00092
-
 substrate beta-phenylethylamine, at high substrate concentration Rattus norvegicus
1.4.3.4 0.00095
-
 substrate 1-methylhistamine, at high substrate concentration Rattus norvegicus
1.4.3.4 0.00125
-
 substrate benzylamine, at high substrate concentration Rattus norvegicus
1.4.3.4 0.00155
-
 substrate tyramine, at high substrate concentration Rattus norvegicus
1.4.3.4 0.00163
-
 substrate beta-phenylethylamine, at high substrate concentration Rattus norvegicus
1.4.3.4 0.00175
-
 substrate tyramine, at high substrate concentration Rattus norvegicus
1.4.3.4 0.00316
-
 substrate serotonin, at low substrate concentration Rattus norvegicus
1.4.3.4 0.0046
-
 substrate serotonin, at high substrate concentration Rattus norvegicus
1.4.3.21 0.00015
-
 substrate benzylamine, at low substrate concentration Rattus norvegicus
1.4.3.21 0.00023
-
 substrate beta-phenylethylamine, at low substrate concentration Rattus norvegicus
1.4.3.21 0.00025
-
 substrate tyramine, at low substrate concentration Rattus norvegicus
1.4.3.21 0.00078
-
 substrate 1-methylhistamine, at low substrate concentration Rattus norvegicus
1.4.3.21 0.00108
-
 substrate tyramine, at high substrate concentration Rattus norvegicus
1.4.3.21 0.00136
-
 substrate beta-phenylethylamine, at high substrate concentration Rattus norvegicus
1.4.3.21 0.00165
-
 substrate 1-methylhistamine, at high substrate concentration Rattus norvegicus
1.4.3.21 0.00193
-
 substrate benzylamine, at high substrate concentration Rattus norvegicus
1.4.3.21 0.00388
-
 substrate serotonin, at high substrate concentration Rattus norvegicus
1.4.3.22 0.00017
-
 substrate histamine, at low substrate concentration Rattus norvegicus
1.4.3.22 0.00037
-
 substrate beta-phenylethylamine, at high substrate concentration Rattus norvegicus
1.4.3.22 0.00074
-
 substrate tyramine, at high substrate concentration Rattus norvegicus
1.4.3.22 0.00075
-
 substrate benzylamine, at high substrate concentration Rattus norvegicus
1.4.3.22 0.00226
-
 substrate histamine, at high substrate concentration Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 1-methylhistamine + H2O + O2 reaction with MAO-A at 1 mM substrate, no activity at 0.1 mM substrate Rattus norvegicus ?
-
 ?
1.4.3.4 1-methylhistamine + H2O + O2 reaction with MAO-B at 1 mM substrate, no activity at 0.1 mM substrate Rattus norvegicus 1-methyl-1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 1-methylhistamine + O2 + H2O
-
 Rattus norvegicus 1-methyl-1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 2-phenylethylamine + H2O + O2 reaction with MAO-A Rattus norvegicus 2-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.4 2-phenylethylamine + H2O + O2 reaction with MAO-B Rattus norvegicus 2-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.4 benzylamine + H2O + O2 reaction with MAO-A Rattus norvegicus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 benzylamine + H2O + O2 reaction with MAO-B Rattus norvegicus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 benzylamine + O2 + H2O
-
 Rattus norvegicus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 beta-phenylethylamine + O2 + H2O
-
 Rattus norvegicus beta-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.4 histamine + H2O + O2 reaction with MAO-B at 1 mM substrate, no activity at 0.1 mM substrate Rattus norvegicus 1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 histamine + H2O + O2 reaction with MAO-A at 1 mM substrate, no activity at 0.1 mM substrate Rattus norvegicus ?
-
 ?
1.4.3.4 histamine + O2 + H2O
-
 Rattus norvegicus 1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 additional information MAOB shows no activity with serotonin Rattus norvegicus ?
-
 ?
1.4.3.4 serotonin + H2O + O2 reaction with MAO-A Rattus norvegicus (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 serotonin + O2 + H2O 5-hydroxytryptamine, MAO-A Rattus norvegicus (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 tyramine + H2O + O2 reaction with MAO-A Rattus norvegicus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 tyramine + H2O + O2 reaction with MAO-B Rattus norvegicus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 tyramine + O2 + H2O
-
 Rattus norvegicus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 1-methylhistamine + O2 + H2O
-
 Rattus norvegicus ?
-
 ?
1.4.3.21 benzylamine + O2 + H2O
-
 Rattus norvegicus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 beta-phenylethylamine + O2 + H2O
-
 Rattus norvegicus beta-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.21 serotonin + O2 + H2O
-
 Rattus norvegicus (5-hydroxy-1H-indol-3yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 tyramine + O2 + H2O
-
 Rattus norvegicus 4-hydroxyphenylethanal + NH3 + H2O2
-
 ?
1.4.3.22 benzylamine + O2 + H2O
-
 Rattus norvegicus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.22 beta-phenylethylamine + O2 + H2O
-
 Rattus norvegicus beta-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.22 histamine + O2 + H2O DAO Rattus norvegicus (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.22 tyramine + O2 + H2O
-
 Rattus norvegicus 1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Rattus norvegicus
1.4.3.4 MAO-B
-
 Rattus norvegicus
1.4.3.4 monoamine oxidase A
-
 Rattus norvegicus
1.4.3.4 monoamine oxidase B
-
 Rattus norvegicus
1.4.3.21 semicarbazide-sensitive amine oxidase
-
 Rattus norvegicus
1.4.3.21 SSAO
-
 Rattus norvegicus
1.4.3.22 DAO
-
 Rattus norvegicus
1.4.3.22 Diamine oxidase
-
 Rattus norvegicus