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Literature summary extracted from
- Inhibition of tyrosinase activity by N,N-unsubstituted selenourea derivatives (2005), Biol. Pharm. Bull., 28, 838—840.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.18.1 | kojic acid | IC50: 0.277 mM | Agaricus bisporus |  |
| 1.14.18.1 | additional information | melan-a cell viability after application of N,N-unsubstituted selenourea derivatives and kojic acid, overview | Agaricus bisporus | |
| 1.14.18.1 | N,N-unsubstituted selenourea derivatives | 55.5% inhibition at 0.2 mM, IC50: 0.17-0.23 mM | Agaricus bisporus | |
| 1.14.18.1 | Phenylthiourea | IC50: 0.17 mM | Agaricus bisporus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | Agaricus bisporus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | commercial preparation | - |
Agaricus bisporus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.1 | additional information | - |
determination of melanin levels | Agaricus bisporus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.1 | 3,4-dihydroxyphenylalanine + O2 | - |
Agaricus bisporus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | tyrosinase | - |
Agaricus bisporus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.18.1 | additional information | - |
additional information | inhibition kinetics | Agaricus bisporus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.14.18.1 | 0.17 | - |
IC50: 0.17 mM | Agaricus bisporus | Phenylthiourea | |
| 1.14.18.1 | 0.17 | 0.23 | 55.5% inhibition at 0.2 mM, IC50: 0.17-0.23 mM | Agaricus bisporus | N,N-unsubstituted selenourea derivatives | |
| 1.14.18.1 | 0.277 | - |
IC50: 0.277 mM | Agaricus bisporus | kojic acid | |
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