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Literature summary extracted from

  • Layer, G.; Kervio, E.; Morlock, G.; Heinz, D.W.; Jahn, D.; Retey, J.; Schubert, W.D.
    Structural and functional comparison of HemN to other radical SAM enzymes (2005), Biol. Chem., 386, 971-980.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.98.3 under strictly anaerobic conditions, comparison of the crystal structures of the three radical SAM enzymes HemN, BioB and MoaA show that the enzymes are structurally significantly different Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.3.98.3 Fe2+ HemN binds a (4Fe-4S) cluster Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Escherichia coli
-
-
-
1.3.98.3 Bacillus subtilis
-
-
-
1.3.98.3 Cereibacter sphaeroides
-
-
-
1.3.98.3 Cupriavidus necator
-
-
-
1.3.98.3 Escherichia coli
-
-
-
1.3.98.3 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.98.3 by a single chromatographic step under anaerobic conditions Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+
-
Escherichia coli protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?
1.3.98.3 coproporphyrinogen-III + S-adenosyl-L-methionine
-
Escherichia coli protoporphyrinogen IX + CO2 + L-methionine + 5'-deoxyadenosine
-
?
1.3.98.3 coproporphyrinogen-III + S-adenosyl-L-methionine
-
Cereibacter sphaeroides protoporphyrinogen IX + CO2 + L-methionine + 5'-deoxyadenosine
-
?

Subunits

EC Number Subunits Comment Organism
1.3.98.3 monomer by crystallographic studies Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
1.3.3.3 CPO
-
Escherichia coli
1.3.3.3 HemF
-
Escherichia coli
1.3.3.3 oxygen-dependent coproporphyrinogen III oxidase
-
Escherichia coli
1.3.98.3 HemN
-
Salmonella enterica subsp. enterica serovar Typhimurium
1.3.98.3 HemN
-
Bacillus subtilis
1.3.98.3 HemN
-
Escherichia coli
1.3.98.3 HemN
-
Cereibacter sphaeroides
1.3.98.3 HemN
-
Cupriavidus necator
1.3.98.3 oxygen-independent coproporphyrinogen III oxidase
-
Salmonella enterica subsp. enterica serovar Typhimurium
1.3.98.3 oxygen-independent coproporphyrinogen III oxidase
-
Bacillus subtilis
1.3.98.3 oxygen-independent coproporphyrinogen III oxidase
-
Escherichia coli
1.3.98.3 oxygen-independent coproporphyrinogen III oxidase
-
Cereibacter sphaeroides
1.3.98.3 oxygen-independent coproporphyrinogen III oxidase
-
Cupriavidus necator

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.98.3 NADH
-
Escherichia coli
1.3.98.3 S-adenosyl-L-methionine HemN binds two SAM molecules Escherichia coli