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Literature summary extracted from

  • Shen, Y.; Tiralongo, J.; Kohla, G.; Schauer, R.
    Regulation of sialic acid O-acetylation in human colon mucosa (2004), Biol. Chem., 385, 145-152.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.45 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid inhibition of O-acetylation in vivo through inhibition of Golgi substrate transporter proteins Homo sapiens
2.3.1.45 CMP
-
 Homo sapiens
2.3.1.45 CoA product inhibition Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.45 Golgi lumen
-
 Homo sapiens 5796
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.45 acetyl-CoA + CMP-N-acetylneuraminic acid Homo sapiens the CMP-N-acetyl-neuraminic acid and acetyl-CoA transporters are critical components for the O-acetylation of CMPNeu5Ac in Golgi lumen, with specific inhibition of either transporter leading to a reduction in the formation of CMP-5-N-acetyl-9-O-acetyl-neuraminic acid, O-acetylation in human colon Golgi vesicles is regulated by the concentration of CMP-Neu5Ac and AcCoA in the lumen, both being under the control of specific transport proteins, overview CoA + CMP-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 additional information Homo sapiens 5-N-acetyl-9-O-acetyl-neuraminic acid can be transferred from neo-synthesised CMP-Neu5,9Ac2 to various endogenous glycoproteins in the same Golgi vesicles ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.45 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.45 colon mucosa Homo sapiens
-
2.3.1.45 colonic cancer cell a reduction of O-acetylation is associated with the early stages of colorectal cancer Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.45 acetyl-CoA + CMP-N-acetylneuraminic acid
-
 Homo sapiens CoA + CMP-N-acetyl-9-O-acetyl-neuraminate the 9-O-acetylsialic acid is the main product ?
2.3.1.45 acetyl-CoA + CMP-N-acetylneuraminic acid the CMP-N-acetyl-neuraminic acid and acetyl-CoA transporters are critical components for the O-acetylation of CMPNeu5Ac in Golgi lumen, with specific inhibition of either transporter leading to a reduction in the formation of CMP-5-N-acetyl-9-O-acetyl-neuraminic acid, O-acetylation in human colon Golgi vesicles is regulated by the concentration of CMP-Neu5Ac and AcCoA in the lumen, both being under the control of specific transport proteins, overview Homo sapiens CoA + CMP-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 additional information 5-N-acetyl-9-O-acetyl-neuraminic acid can be transferred from neo-synthesised CMP-Neu5,9Ac2 to various endogenous glycoproteins in the same Golgi vesicles Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.45 7(9)-OAT
-
 Homo sapiens
2.3.1.45 sialate-7(9)-O-acetyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.45 37
-
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.45 7
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.45 acetyl-CoA
-
 Homo sapiens