EC Number | Application | Comment | Organism |
---|---|---|---|
1.2.1.8 | medicine | betaine aldehyde dehydrogenase is a potential target for antimicrobial agents against Pseudomonas aeruginosa | Pseudomonas aeruginosa |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.2.1.8 | C353A | steady-state kinetic and structure not significantly affected | Pseudomonas aeruginosa |
1.2.1.8 | C377A | steady-state kinetic and structure not significantly affected | Pseudomonas aeruginosa |
1.2.1.8 | C439A | steady-state kinetic and structure not significantly affected, stability severely reduced | Pseudomonas aeruginosa |
1.2.1.8 | C439S | steady-state kinetic and structure not significantly affected, stability severely reduced | Pseudomonas aeruginosa |
1.2.1.8 | C439V | steady-state kinetic and structure not significantly affected, stability severely reduced | Pseudomonas aeruginosa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.8 | additional information | - |
additional information | for the mutants and wild-type enzymes KM NADP+ varies within 0.060 and 0.107 mM, KM NAD+ within 0.254 and 0.411 mM, KM betaine aldehyde within 0.270 and 0.434 mM | Pseudomonas aeruginosa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.8 | betaine aldehyde + NAD(P)+ + H2O | Pseudomonas aeruginosa | - |
glycine betaine + NAD(P)H + 2 H+ | - |
ir |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.8 | Pseudomonas aeruginosa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.8 | purified to homogeneity following a two-step procedure, proteins expressed in Escherichia coli | Pseudomonas aeruginosa |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.2.1.8 | 75 | - |
mutant C439V | Pseudomonas aeruginosa |
1.2.1.8 | 102 | - |
mutant C439S | Pseudomonas aeruginosa |
1.2.1.8 | 138 | - |
mutant C353A | Pseudomonas aeruginosa |
1.2.1.8 | 165 | - |
mutant C377A | Pseudomonas aeruginosa |
1.2.1.8 | 189 | - |
mutant C439A | Pseudomonas aeruginosa |
1.2.1.8 | 196 | - |
wild-type enzyme | Pseudomonas aeruginosa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.8 | betaine aldehyde + NAD(P)+ + H2O | - |
Pseudomonas aeruginosa | glycine betaine + NAD(P)H + 2 H+ | - |
ir |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.2.1.8 | homotetramer | - |
Pseudomonas aeruginosa |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.1.8 | BADH | - |
Pseudomonas aeruginosa |
1.2.1.8 | betaine aldehyde dehydrogenase | - |
Pseudomonas aeruginosa |
1.2.1.8 | betaine aldehyde:NAD+ oxidoreductase | - |
Pseudomonas aeruginosa |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.2.1.8 | 34.3 | - |
apparent T50 mutant C439V | Pseudomonas aeruginosa |
1.2.1.8 | 37 | - |
apparent T50 mutant C439S | Pseudomonas aeruginosa |
1.2.1.8 | 43.6 | - |
apparent T50 mutant C439A | Pseudomonas aeruginosa |
1.2.1.8 | 46 | - |
apparent T50 mutant C377A | Pseudomonas aeruginosa |
1.2.1.8 | 49.4 | - |
apparent T50 mutant C353A | Pseudomonas aeruginosa |
1.2.1.8 | 50.7 | - |
apparent T50 wild-type enzyme | Pseudomonas aeruginosa |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.8 | NAD(P)+ | - |
Pseudomonas aeruginosa |