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Literature summary extracted from

  • Huwiler, A.; Doell, F.; Ren, S.; Klawitter, S.; Greening, A.; Roemer, I.; Bubnova, S.; Reinsberg, L.; Pfeilschifter, J.
    Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism (2006), Biochim. Biophys. Acta, 1761, 367-376.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.91 12-O-tetradecanoylphorbol-13-acetate 50 nM, maximum increase in activity after 24 h Homo sapiens
2.7.1.91 histamine 0.001 mM, up to 5fold increase of activity after 20 h Homo sapiens
2.7.1.91 additional information not activated by histamine or 12-O-tetradecanoylphorbol-13-acetate Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.91 expressed in HEK-293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.91 KCl 1 mM Homo sapiens
2.7.1.91 additional information not inhibited by KCl Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.91 cytoplasm
-
 Homo sapiens 5737
-
2.7.1.91 nucleus
-
 Homo sapiens 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.91 42000
-
 SDS-PAGE, splice variant SK-1a Homo sapiens
2.7.1.91 51000
-
 SDS-PAGE, splice variant SK-1b Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Homo sapiens Q9NRA0
-
-
2.7.1.91 Homo sapiens Q9NYA1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 EAhy 926 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.91 ATP + sphingosine
-
 Homo sapiens ADP + sphingosine 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.91 SK-1
-
 Homo sapiens
2.7.1.91 SK-2
-
 Homo sapiens
2.7.1.91 sphinganine kinase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.91 ATP
-
 Homo sapiens