Literature summary extracted from

Murphy, C.; Parini, P.; Wang, J.; Bjoerkhem, I.; Eggertsen, G.; Gafvels, M.
Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice (2005), Biochim. Biophys. Acta, 1735, 167-175.

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.14.14.139	additional information	construction of male CYP8B1 knockout mice, the mutant mice show increased cholesterol synthesis with normal diet, and decreased cholesterol absorption under cholesterol diet and feeding of cholic acid, they accumulate less cholesteryl esters compared to wild-type mice, phenotype, overview	Mus musculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.14.139	additional information	cholic acid suppresses expression of CYP8B1	Mus musculus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.14.14.139	microsome	-	Mus musculus	-	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.14.139	cholesterol + [reduced NADPH-hemoprotein reductase] + O2	Mus musculus	dietary cholsterol and cholic acid have an influence of enzyme regulation	12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.14.139	Mus musculus	-	male C75B1/6 mice	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.14.139	liver	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.14.139	cholesterol + [reduced NADPH-hemoprotein reductase] + O2	-	Mus musculus	12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
1.14.14.139	cholesterol + [reduced NADPH-hemoprotein reductase] + O2	dietary cholsterol and cholic acid have an influence of enzyme regulation	Mus musculus	12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.14.139	CYP8B1	-	Mus musculus
1.14.14.139	sterol 12alpha-hydroxylase	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)