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Literature summary extracted from

  • Ott, R.G.; Athenstaedt, K.; Hrastnik, C.; Leitner, E.; Bergler, H.; Daum, G.
    Flux of sterol intermediates in a yeast strain deleted of the lanosterol C-14 demethylase Erg11p (2005), Biochim. Biophys. Acta, 1735, 111-118.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.154 expression of N-terminally GFP-tagged enzyme in strain FYN8 under control of the GAL1 promoter Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.154 additional information construction of a deletion mutant strain DELTAerg11, the defect is lethal, but mutants survive in a DELTAerg3 background, erg11/erg3 mutant lacks ergosterol but compensates the lack, sterol distrubution is altered, mutant sterol composition and phenotype, overview Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.154 endoplasmic reticulum distribution of Erg proteins between endoplasmic reticulum and liquid particles in wild-type and DELTAerg11-DELTAerg3 mutant, overview Saccharomyces cerevisiae 5783
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1.14.14.154 membrane
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 Saccharomyces cerevisiae 16020
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 Saccharomyces cerevisiae deletion of the enzyme is lethal 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 Saccharomyces cerevisiae FY1679 deletion of the enzyme is lethal 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Saccharomyces cerevisiae
-
-
-
1.14.14.154 Saccharomyces cerevisiae FY1679
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Saccharomyces cerevisiae 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 deletion of the enzyme is lethal Saccharomyces cerevisiae 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Saccharomyces cerevisiae FY1679 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.154 lanosterol + [reduced NADPH-hemoprotein reductase] + O2 deletion of the enzyme is lethal Saccharomyces cerevisiae FY1679 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.154 Erg11p
-
 Saccharomyces cerevisiae
1.14.14.154 lanosterol C-14 demethylase
-
 Saccharomyces cerevisiae