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Literature summary extracted from

  • Tsaplina, L.A.; Karatasso, Y.O.; Filimonov, I.S.; Vrzheshch, P.V.
    Kinetic mechanism of the bifunctional enzyme prostaglandin-H-synthase. Effect of electron donors on the cyclooxygenase reaction (2006), Biochemistry (Moscow), 71, 1247-1255.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.1 naproxen inhibitor of cyclooxigenase reaction; inhibitor of cyclooxigenase reaction Ovis aries

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.99.1 microsome
-
Ovis aries
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.99.1 72000
-
monomer Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.1 arachidonate + AH2 + O2 Ovis aries
-
prostaglandin H2 + A + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.1 Ovis aries P05979 PGHS-1 precursor
-
1.14.99.1 Ovis aries P79208 PGHS-2 precursor
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.1 arachidonate + AH2 + O2
-
Ovis aries prostaglandin H2 + A + H2O
-
?
1.14.99.1 arachidonic acid + 2 O2 cyclooxygenase reaction, arachidonic acid as electron donor Ovis aries prostaglandin G2
-
?

Subunits

EC Number Subunits Comment Organism
1.14.99.1 homodimer
-
Ovis aries

Synonyms

EC Number Synonyms Comment Organism
1.14.99.1 PGHS
-
Ovis aries
1.14.99.1 PGHS-1 one of two isoforms found in mammalian cells, always present and provides their normal functioning Ovis aries
1.14.99.1 PGHS-2 one of two isoforms found in mammalian cells, produced in response to certain stimuli, such as cytokines and growth factors Ovis aries
1.14.99.1 prostaglandin-endoperoxide synthase
-
Ovis aries
1.14.99.1 prostaglandin-H-synthase
-
Ovis aries

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.99.1 25
-
kinetic assay Ovis aries

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.99.1 8
-
kinetic assay Ovis aries