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Literature summary extracted from

  • Wang, Y.; Lamarche, B.J.; Tsai, M.D.
    Human DNA ligase IV and the ligase IV/XRCC4 complex: analysis of nick ligation fidelity (2007), Biochemistry, 46, 4962-4976.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.5.1.1 Escherichia coli-based coexpression system provides relatively high yields of the ligase IV/XRCC4 complex Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens ligase IV/XRCC4 is the sole DNA ligase involved in the repair of double strand breaks via the non-homologous end joining pathway. Analogous to most other DNA ligases, ligase IV/XRCC4 is fairly intolerant of nicks containing mismatched base pairs AMP + diphosphate + (deoxyribonucleotide)n+m
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Homo sapiens P49917
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.5.1.1
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.5.1.1 hippocampus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m ligase IV/XRCC4 is the sole DNA ligase involved in the repair of double strand breaks via the non-homologous end joining pathway. Analogous to most other DNA ligases, ligase IV/XRCC4 is fairly intolerant of nicks containing mismatched base pairs Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 DNA ligase 4
-
 Homo sapiens
6.5.1.1 DNA ligase IV
-
 Homo sapiens