Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Howard-Jones, A.R.; Elkins, J.M.; Clifton, I.J.; Roach, P.L.; Adlington, R.M.; Baldwin, J.E.; Rutledge, P.J.
    Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight (2007), Biochemistry, 46, 4755-4762.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.21.3.1 in complex with tripeptyl analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-beta-methyl-D-cyclopropylglycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-cyclopropylglycine, crystallization in presence of Fe-(II) under anaerobic conditions Aspergillus nidulans

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.3.1 delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-cyclopropylglycine
-
Aspergillus nidulans

Organism

EC Number Organism UniProt Comment Textmining
1.21.3.1 Aspergillus nidulans P05326
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O radical pathway, analogous to the first step of a radicalbased hydroxylation reaction Aspergillus nidulans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.3.1 delta-(L-alpha-aminoadipoyl)-L-cysteinyl-beta-methyl-D-cyclopropylglycine + O2
-
Aspergillus nidulans (2R,8R)-8-([(5S)-5-amino-5-carboxypentanoyl]amino)-3-methylene-9-oxo-6-thia-1-azabicyclo[5.2.0]nonane-2-carboxylic acid + H2O
-
?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
Aspergillus nidulans isopenicillin N + 2 H2O
-
?