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Literature summary extracted from

  • Nicely, N.I.; Parsonage, D.; Paige, C.; Newton, G.L.; Fahey, R.C.; Leonardi, R.; Jackowski, S.; Mallett, T.C.; Claiborne, A.
    Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology (2007), Biochemistry, 46, 3234-3245.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.33
-
 Bacillus anthracis
2.7.1.33 expressed in Escherichia coli strain C41(DE3) Bacillus anthracis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.33 sitting drop vapour diffusion method using 24-26% ethylene glycol Bacillus anthracis
2.7.1.33 sitting-drop method. The crystal structure of Bacillus anthracis PanK is solved using multiwavelength anomalous dispersion data and refined at a resolution of 2.0 A Bacillus anthracis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.33 additional information the enzyme is not subject to feedback inhibition by CoASH Bacillus anthracis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.33 additional information Bacillus anthracis type III PanK in the spore-forming Bacillus anthracis plays an essential role in the novel thiol/disulfide redox biology of this category A biodefense pathogen ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.33 Bacillus anthracis
-
-
-
2.7.1.33 Bacillus anthracis Q81VX4
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.33
-
 Bacillus anthracis
2.7.1.33 Ni-NTA column chromatography Bacillus anthracis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.33 ATP + (R)-pantothenate
-
 Bacillus anthracis ADP + (R)-4'-phosphopantothenate
-
 ?
2.7.1.33 additional information type III PanK in the spore-forming Bacillus anthracis plays an essential role in the novel thiol/disulfide redox biology of this category A biodefense pathogen Bacillus anthracis ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.33 monomer x-ray crystallography Bacillus anthracis

Synonyms

EC Number Synonyms Comment Organism
2.7.1.33 BaPanK
-
 Bacillus anthracis
2.7.1.33 PanK
-
 Bacillus anthracis
2.7.1.33 type III pantothenate kinase
-
 Bacillus anthracis

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.33 ATP
-
 Bacillus anthracis