Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hall, D.D.; Davare, M.A.; Shi, M.; Allen, M.L.; Weisenhaus, M.; McKnight, G.S.; Hell, J.W.
    Critical role of cAMP-dependent protein kinase anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons (2007), Biochemistry, 46, 1635-1646.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP
-
 Rattus norvegicus
2.7.11.11 additional information beta-adrenergic stimulation of Ser1928 phosphorylation, L-type calcium channel Cav1.2 constitutively associates with the beta2-AR and PKA to efficiently respond to beta-adrenergic activation Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.11 additional information deletion of the AKAP150 gene abrogates stimulation of alpha11.2 phosphorylation on Ser1928 in vivo, overview Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 ATP + A-kinase anchor protein Rattus norvegicus phosphorylation at Ser1928 ADP + phosphorylated A-kinase anchor protein
-
 ?
2.7.11.11 ATP + Cav1.2 Rattus norvegicus in anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons plays a critical role involving phosphorylation by the enzyme, PKA increases the activity of the L-type Ca2+ channel Cav1.2 in response to beta-adrenergic stimulation in heart and brain ADP + phosphorylated Cav1.2
-
 ?
2.7.11.11 additional information Rattus norvegicus enzyme regulation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Rattus norvegicus
-
 male Harlan Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 brain
-
 Rattus norvegicus
-
2.7.11.11 heart
-
 Rattus norvegicus
-
2.7.11.11 neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + A-kinase anchor protein phosphorylation at Ser1928 Rattus norvegicus ADP + phosphorylated A-kinase anchor protein
-
 ?
2.7.11.11 ATP + A-kinase anchor protein i.e. AKAP, phosphorylation at Ser1928, the rat enzyme is active with different AKAP substrate variants from different sources, overview Rattus norvegicus ADP + phosphorylated A-kinase anchor protein
-
 ?
2.7.11.11 ATP + Cav1.2 in anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons plays a critical role involving phosphorylation by the enzyme, PKA increases the activity of the L-type Ca2+ channel Cav1.2 in response to beta-adrenergic stimulation in heart and brain Rattus norvegicus ADP + phosphorylated Cav1.2
-
 ?
2.7.11.11 ATP + Cav1.2 an L-type calcium channel Cav1.2 Rattus norvegicus ADP + phosphorylated Cav1.2
-
 ?
2.7.11.11 additional information enzyme regulation, overview Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Rattus norvegicus