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Literature summary extracted from

  • Xiong, Y.; Bernardi, D.; Bratton, S.; Ward, M.D.; Battaglia, E.; Finel, M.; Drake, R.R.; Radominska-Pandya, A.
    Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and site-directed mutagenesis (2006), Biochemistry, 45, 2322-2332.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 expression of His-tagged enzyme in baculovirus-infected Sf9 insect cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 4-azido-2-hydroxybenzoic acid inhibition of UGT1A10 catalyzed glucuronidation of 4-nitrophenol Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.0496
-
 4-nitrophenol 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.0522
-
 4-Methylumbelliferone 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.0766
-
 4-Methylumbelliferone 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.0924
-
 4-Methylumbelliferone 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.1226
-
 4-Methylumbelliferone 37°C Homo sapiens
2.4.1.17 0.1508
-
 4-nitrophenol 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.2376
-
 4-Methylumbelliferone 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.3359
-
 4-nitrophenol 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.5191
-
 4-nitrophenol 37°C, pH 7.4 Homo sapiens
2.4.1.17 0.803
-
 4-nitrophenol 37°C, pH 7.4 Homo sapiens
2.4.1.17 1.034
-
 4-nitrophenol 37°C, pH 7.4 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens O60656
-
-
2.4.1.17 Homo sapiens P19224
-
-
2.4.1.17 Homo sapiens P22309
-
-
2.4.1.17 Homo sapiens Q9HAW7
-
-
2.4.1.17 Homo sapiens Q9HAW8
-
-
2.4.1.17 Homo sapiens Q9HAW9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 3-azido-4-chlorobenzoic acid + UDP-glucuronate
-
 Homo sapiens ?
-
 ?
2.4.1.17 3-azidobenzoic acid + UDP-glucuronate
-
 Homo sapiens ?
-
 ?
2.4.1.17 4-azido-2-hydroxybenzoic acid + UDPglucuronate
-
 Homo sapiens ?
-
 ?
2.4.1.17 4-azidobenzoic acid + UDP-glucuronate
-
 Homo sapiens ?
-
 ?
2.4.1.17 4-methylumbelliferone + UDP-glucuronate
-
 Homo sapiens UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
 ?
2.4.1.17 4-methylumbelliferone + UDP-glucuronate Phe90 and Phe93 are directly involved in the catalytic activity of UGT1A10 towards 4-methylumbelliferone Homo sapiens UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
 ?
2.4.1.17 4-nitrophenol + UDP-glucuronate
-
 Homo sapiens 4-nitrophenyl beta-D-glucuronide + UDP
-
 ?
2.4.1.17 4-nitrophenol + UDP-glucuronate Phe90 and Phe93 are directly involved in the catalytic activity of UGT1A10 towards 4-nitrophenol Homo sapiens 4-nitrophenyl beta-D-glucuronide + UDP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase 1A1
-
 Homo sapiens
2.4.1.17 UDP-glucuronosyltransferase 1A10
-
 Homo sapiens
2.4.1.17 UDP-glucuronosyltransferase 1A6
-
 Homo sapiens
2.4.1.17 UDP-glucuronosyltransferase 1A7
-
 Homo sapiens
2.4.1.17 UDP-glucuronosyltransferase 1A8
-
 Homo sapiens
2.4.1.17 UDP-glucuronosyltransferase 1A9
-
 Homo sapiens
2.4.1.17 UGT-1J
-
 Homo sapiens
2.4.1.17 UGT1-10
-
 Homo sapiens
2.4.1.17 UGT1.10
-
 Homo sapiens
2.4.1.17 UGT1A1
-
 Homo sapiens
2.4.1.17 UGT1A6
-
 Homo sapiens
2.4.1.17 UGT1A7
-
 Homo sapiens
2.4.1.17 UGT1A8
-
 Homo sapiens
2.4.1.17 UGT1A9
-
 Homo sapiens
2.4.1.17 UGT1J
-
 Homo sapiens