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Literature summary extracted from

  • Rao, K.S.; Albro, M.; Zirrolli, J.A.; Vander Velde, D.; Jones, D.N.M.; Frerman, F.E.
    Protonation of crotonyl-CoA dienolate by human glutaryl-CoA dehydrogenase occurs by solvent-derived protons (2005), Biochemistry, 44, 13932-13940.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.8.6 expressed in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.3.8.6 E370Q does not catalyze detectable exchange of 4c methyl protons of crotonyl-CoA Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.8.6 0.0034
-
 glutaryl-CoA
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.6 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.8.6
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.6 glutaconyl-CoA + acceptor involvement of water in catalysis, previously unrecognized and in conflict with a classically held intramolecular 1,3-prototropic shift for protonation of crotonyl-CoA dienolate Homo sapiens crotonyl-CoA + CO2 + reduced acceptor
-
 ?
1.3.8.6 glutaryl-CoA + acceptor
-
 Homo sapiens crotonoyl-CoA + CO2 + reduced acceptor
-
 ?
1.3.8.6 octanoyl-CoA + acceptor
-
 Homo sapiens ? + reduced acceptor
-
 ?
1.3.8.6 proteo-glutaryl-CoA + acceptor
-
 Homo sapiens crotonoyl-CoA + CO2 + reduced acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.8.6 GCD
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.3.8.6 3.87
-
 glutaryl-CoA
-
 Homo sapiens