Literature summary extracted from

  • Long, M.C.; Parker, W.B.
    Structure-activity relationship for nucleoside analogs as inhibitors or substrates of adenosine kinase from Mycobacterium tuberculosis. I. Modifications to the adenine moiety (2006), Biochem. Pharmacol., 71, 1671-1682.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.20 1-(4-fluorobenzyloxy)-adenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 1-deaza-2-amino-6-chloropurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-(1-ethyn-1-yl)-adenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-amino-6-oxypurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-Aminoadenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-azaadenosine 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-azidoadenosine 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-azido-O6-methylinosine 0.1 mM, 10-90% inhibition Homo sapiens
2.7.1.20 2-azido-O6-methylinosine 0.001 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-bromoadenosine 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-chloro-6-methoxypurine riboside 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-chloroadenosine 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-chloropurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2'-deoxycoformycin 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-ethyladenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-fluoro-3-deazaadenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-fluoro-8-azaadenosine 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-fluoroadenosine 0.1 mM, 10-90% inhibition Homo sapiens
2.7.1.20 2-fluoroadenosine 0.001 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-hydroxyadenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-methyl-6-oxypurine riboside 0.001 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-methyladenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-methyl-N6-benzoyladenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-methyl-N6-octyladenosine 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2-methyl-S6-phenyl-6-mercaptopurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2,N6-dimethyladenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 2,O6-dimethylinosine 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 3-deazaadenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 6-benzylmercaptopurine riboside 0.1 mM, 10-90% inhibition Homo sapiens
2.7.1.20 6-benzylmercaptopurine riboside 0.001 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 6-bromopurine riboside 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 6-Chloropurine riboside 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 6-cyclopentyloxypurine riboside 0.1 mM, 10-90% inhibition Homo sapiens
2.7.1.20 6-cyclopentyloxypurine riboside 0.001 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 6-fluoro-8-aminopurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 6-fluoromethylpurine riboside 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 6-iodopurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 6-mercaptopurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 6-methoxypurine riboside 0.1 mM, 10-90% inhibition Homo sapiens
2.7.1.20 6-methoxypurine riboside 0.001 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 6-Methylmercaptopurine riboside 0.1 mM, 10-90% inhibition Homo sapiens
2.7.1.20 6-Methylmercaptopurine riboside 0.001 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 6-methylpurine riboside 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 6-nitrobenzylmercaptopurine riboside 0.1 mM, 10-90% inhibition Homo sapiens
2.7.1.20 6-nitrobenzylmercaptopurine riboside 0.001 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 7-cyano-7-deazaadenosine 0.001 mM, 10-90% inhibition Homo sapiens
2.7.1.20 7-cyano-7-deazaadenosine 0.001 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 7-deaza-7-carboxamidoadenosine 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 7-deazaadenosine 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 7-iodo-7-deazaadenosine 0.0001 mM, 10-90% inhibition Homo sapiens
2.7.1.20 7-iodo-7-deazaadenosine 0.001 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 8-aminopurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 8-aza-9-deazaadenosine 0.1 mM, 10-90% inhibition Homo sapiens
2.7.1.20 8-aza-9-deazaadenosine 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 8-azaadenosine 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 8-azidoadenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 8-azidopurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 8-Bromoadenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 8-bromopurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 8-chloroadenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 8-chloropurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 8-dimethylaminopurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 8-hydroxypurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 8-mercaptopurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 8-methoxypurine riboside 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 9-[beta-D-ribofuranosyl]purine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 9-deazaadenosine 0.01 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 adenosine-N1-oxide 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 cytidine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 N1-benzyladenosine 0.1 mM, 10-90% inhibition Homo sapiens
2.7.1.20 N1-benzyladenosine 0.001 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 N1-ethyladenosine 0.1 mM, 10-90% inhibition Homo sapiens
2.7.1.20 N1-ethyladenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 N1-methyladenosine 0.1 mM, 10-90% inhibition Homo sapiens
2.7.1.20 N1-methyladenosine 0.001 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 N1-oxy-N6-methyladenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 N6-aminoadenosine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis
2.7.1.20 uridine 0.1 mM, 10-90% inhibition Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.20 Homo sapiens
-
-
-
2.7.1.20 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.20 ATP + adenosine
-
Homo sapiens ADP + AMP
-
?
2.7.1.20 ATP + adenosine
-
Mycobacterium tuberculosis ADP + AMP
-
?
2.7.1.20 ATP + 2-azaadenosine
-
Homo sapiens ADP + 2-azaadenosine 5'-phosphate
-
?
2.7.1.20 ATP + 2-azaadenosine
-
Mycobacterium tuberculosis ADP + 2-azaadenosine 5'-phosphate
-
?
2.7.1.20 ATP + 2-chloroadenosine
-
Homo sapiens ADP + 2-chloroadenosine 5'-phosphate
-
?
2.7.1.20 ATP + 2-chloroadenosine
-
Mycobacterium tuberculosis ADP + 2-chloroadenosine 5'-phosphate
-
?
2.7.1.20 ATP + 2-fluoroadenosine
-
Homo sapiens ADP + 2-fluoroadenosine 5'-phosphate
-
?
2.7.1.20 ATP + 2-fluoroadenosine
-
Mycobacterium tuberculosis ADP + 2-fluoroadenosine 5'-phosphate
-
?
2.7.1.20 ATP + 6-bromopurine riboside
-
Homo sapiens ADP + 6-bromopurine riboside 5'-phosphate
-
?
2.7.1.20 ATP + 6-chloropurine riboside
-
Homo sapiens ADP + 6-chloropurine riboside 5'-phosphate
-
?
2.7.1.20 ATP + 6-fluoromethylpurine riboside
-
Homo sapiens ADP + 6-fluoromethylpurine riboside 5'-phosphate
-
?
2.7.1.20 ATP + 8-aza-9-deazaadenosine
-
Homo sapiens ADP + 8-aza-9-deazaadenosine 5'-phosphate
-
?
2.7.1.20 ATP + 8-aza-9-deazaadenosine
-
Mycobacterium tuberculosis ADP + 8-aza-9-deazaadenosine 5'-phosphate
-
?
2.7.1.20 ATP + 8-azaadenosine
-
Homo sapiens ADP + 8-azaadenosine 5'-phosphate
-
?
2.7.1.20 ATP + 9-[beta-D-ribofuranosyl]-purine
-
Homo sapiens ADP + 9-[beta-D-ribofuranosyl]-purine 5'-phosphate
-
?
2.7.1.20 ATP + adenosine-N1-oxide
-
Homo sapiens ADP + adenosine-N1-oxide 5'-phosphate
-
?
2.7.1.20 ATP + N1-oxy-N6-methyladenosine
-
Homo sapiens ADP + N1-oxy-N6-methyladenosine 5'-phosphate
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.20 0.0005
-
2-fluoroadenosine
-
Homo sapiens
2.7.1.20 0.0005
-
2-fluoroadenosine
-
Mycobacterium tuberculosis
2.7.1.20 0.0058
-
8-aza-9-deazaadenosine
-
Homo sapiens
2.7.1.20 0.0058
-
8-aza-9-deazaadenosine
-
Mycobacterium tuberculosis
2.7.1.20 0.00015
-
6-cyclopentyloxypurine riboside
-
Homo sapiens
2.7.1.20 0.00015
-
6-cyclopentyloxypurine riboside
-
Mycobacterium tuberculosis
2.7.1.20 0.00019
-
N1-benzyladenosine
-
Homo sapiens
2.7.1.20 0.00019
-
N1-benzyladenosine
-
Mycobacterium tuberculosis
2.7.1.20 0.00021
-
7-iodo-7-deazaadenosine
-
Homo sapiens
2.7.1.20 0.00021
-
7-iodo-7-deazaadenosine
-
Mycobacterium tuberculosis