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Literature summary extracted from

  • Ricci, L.; Frosini, M.; Gaggelli, N.; Valensin, G.; Machetti, F.; Sgaragli, G.; Valoti, M.
    Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis (2006), Biochem. Pharmacol., 71, 1510-1519.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 (+/-)piperidine-3-sulfonic acid
-
 Oryctolagus cuniculus
2.6.1.19 2-Aminobenzenesulfonate
-
 Oryctolagus cuniculus
2.6.1.19 2-aminoethane phosphonic acid
-
 Oryctolagus cuniculus
2.6.1.19 2-N-(acetylamino)cyclohexane sulfonic acid
-
 Oryctolagus cuniculus
2.6.1.19 vigabatrin
-
 Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.19 12.8
-
 4-aminobutanoate at pH 8.4 and 38°C Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.19 partially Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 brain
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.19 additional information
-
 3.4 units/mg in crude brain homogenate and 51.2 units/mg after 15fold purification Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Oryctolagus cuniculus 4-oxobutanoate + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.19 GABA-T
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.19 pyridoxal 5'-phosphate 0.1 mM Oryctolagus cuniculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.19 0.32
-
 vigabatrin competitive inhibition at 37°C Oryctolagus cuniculus
2.6.1.19 0.364
-
 (+/-)piperidine-3-sulfonic acid mixed inhibition at 37°C Oryctolagus cuniculus
2.6.1.19 0.434
-
 2-Aminobenzenesulfonate competitive inhibition at 37°C Oryctolagus cuniculus
2.6.1.19 0.598
-
 2-N-(acetylamino)cyclohexane sulfonic acid competitive inhibition at 37°C Oryctolagus cuniculus
2.6.1.19 1.01
-
 2-aminoethane phosphonic acid competitive inhibition at 37°C Oryctolagus cuniculus