BRENDA - Enzyme Database show

Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells

Smal, C.; Cardoen, S.; Betrand, L.; Delacauw, A.; Ferrant, A.; Van den Berghe, G.; Van den Neste, E.; Bontemps, F.; Biochem. Pharmacol. 69, 95-103 (2003)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.74
2-chloro-2'-deoxyadenosine
-
Homo sapiens
2.7.1.74
AG-490
-
Homo sapiens
2.7.1.74
daidzein
-
Homo sapiens
2.7.1.74
genistein
-
Homo sapiens
2.7.1.74
okadaic acid
-
Homo sapiens
2.7.1.74
PD-98059
-
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.74
H-7
reduces the enzyme activation caused by the addition of 2-chloro-2’-deoxyadenosine
Homo sapiens
2.7.1.74
protein phosphatase lambda
-
Homo sapiens
2.7.1.74
staurosporine
reduces the enzyme activation caused by the addition of 2-chloro-2’-deoxyadenosine
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
ATP + 2'-deoxyadenosine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
2.7.1.74
ATP + 2'-deoxycytidine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
2.7.1.74
additional information
Homo sapiens
key enzyme in the deoxynucleoside salvage pathway and in the activation of numerous nucleoside analogues used in cancer and antiviral chemotherapy
?
-
-
-
2.7.1.74
NTP + 2-chloro-2'-deoxyadenosine
Homo sapiens
i.e. cladribine, activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies
NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
?
2.7.1.74
NTP + 9-beta-D-arabinosyl 2-fluoroadenine
Homo sapiens
activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies
NDP + 9-beta-D-arabinosyl 2-fluoroadenine 5'-phosphate
-
-
?
2.7.1.74
UTP + 2',3'-dideoxycytidine
Homo sapiens
i.e. zalcitabine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections
UDP + 2',3'-dideoxycytidine 5'-phosphate
-
-
?
2.7.1.74
UTP + 2'-deoxy-3'-thiacytidine
Homo sapiens
i.e. lamivudine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections
UDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
-
?
2.7.1.74
UTP + 2'-deoxyadenosine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
UDP + 2'-deoxyadenosine 5'-phosphate
-
-
?
2.7.1.74
UTP + 2'-deoxycytidine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
UDP + 2'-deoxycytidine 5'-phosphate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Homo sapiens
-
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
2.7.1.74
phosphoprotein
phosphorylation of the enzyme involved in the regulation of enzyme activity
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
CCRF-CEM cell
-
Homo sapiens
-
2.7.1.74
EHEB cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxyadenosine
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
671911
Homo sapiens
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + 2'-deoxycytidine
-
671911
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + 2'-deoxycytidine
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
671911
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
additional information
key enzyme in the deoxynucleoside salvage pathway and in the activation of numerous nucleoside analogues used in cancer and antiviral chemotherapy
671911
Homo sapiens
?
-
-
-
-
2.7.1.74
NTP + 2-chloro-2'-deoxyadenosine
i.e. cladribine, activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies
671911
Homo sapiens
NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.74
NTP + 9-beta-D-arabinosyl 2-fluoroadenine
activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies
671911
Homo sapiens
NDP + 9-beta-D-arabinosyl 2-fluoroadenine 5'-phosphate
-
-
-
?
2.7.1.74
UTP + 2',3'-dideoxycytidine
i.e. zalcitabine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections
671911
Homo sapiens
UDP + 2',3'-dideoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
UTP + 2'-deoxy-3'-thiacytidine
i.e. lamivudine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections
671911
Homo sapiens
UDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
-
-
?
2.7.1.74
UTP + 2'-deoxyadenosine
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
671911
Homo sapiens
UDP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.74
UTP + 2'-deoxycytidine
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
671911
Homo sapiens
UDP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
2.7.1.74
UTP
-
Homo sapiens
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.74
2-chloro-2'-deoxyadenosine
-
Homo sapiens
2.7.1.74
AG-490
-
Homo sapiens
2.7.1.74
daidzein
-
Homo sapiens
2.7.1.74
genistein
-
Homo sapiens
2.7.1.74
okadaic acid
-
Homo sapiens
2.7.1.74
PD-98059
-
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
2.7.1.74
UTP
-
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.74
H-7
reduces the enzyme activation caused by the addition of 2-chloro-2’-deoxyadenosine
Homo sapiens
2.7.1.74
protein phosphatase lambda
-
Homo sapiens
2.7.1.74
staurosporine
reduces the enzyme activation caused by the addition of 2-chloro-2’-deoxyadenosine
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
ATP + 2'-deoxyadenosine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
2.7.1.74
ATP + 2'-deoxycytidine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
2.7.1.74
additional information
Homo sapiens
key enzyme in the deoxynucleoside salvage pathway and in the activation of numerous nucleoside analogues used in cancer and antiviral chemotherapy
?
-
-
-
2.7.1.74
NTP + 2-chloro-2'-deoxyadenosine
Homo sapiens
i.e. cladribine, activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies
NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
?
2.7.1.74
NTP + 9-beta-D-arabinosyl 2-fluoroadenine
Homo sapiens
activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies
NDP + 9-beta-D-arabinosyl 2-fluoroadenine 5'-phosphate
-
-
?
2.7.1.74
UTP + 2',3'-dideoxycytidine
Homo sapiens
i.e. zalcitabine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections
UDP + 2',3'-dideoxycytidine 5'-phosphate
-
-
?
2.7.1.74
UTP + 2'-deoxy-3'-thiacytidine
Homo sapiens
i.e. lamivudine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections
UDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
-
?
2.7.1.74
UTP + 2'-deoxyadenosine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
UDP + 2'-deoxyadenosine 5'-phosphate
-
-
?
2.7.1.74
UTP + 2'-deoxycytidine
Homo sapiens
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
UDP + 2'-deoxycytidine 5'-phosphate
-
-
?
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
2.7.1.74
phosphoprotein
phosphorylation of the enzyme involved in the regulation of enzyme activity
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
CCRF-CEM cell
-
Homo sapiens
-
2.7.1.74
EHEB cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxyadenosine
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
671911
Homo sapiens
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + 2'-deoxycytidine
-
671911
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + 2'-deoxycytidine
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
671911
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
additional information
key enzyme in the deoxynucleoside salvage pathway and in the activation of numerous nucleoside analogues used in cancer and antiviral chemotherapy
671911
Homo sapiens
?
-
-
-
-
2.7.1.74
NTP + 2-chloro-2'-deoxyadenosine
i.e. cladribine, activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies
671911
Homo sapiens
NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.74
NTP + 9-beta-D-arabinosyl 2-fluoroadenine
activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies
671911
Homo sapiens
NDP + 9-beta-D-arabinosyl 2-fluoroadenine 5'-phosphate
-
-
-
?
2.7.1.74
UTP + 2',3'-dideoxycytidine
i.e. zalcitabine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections
671911
Homo sapiens
UDP + 2',3'-dideoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
UTP + 2'-deoxy-3'-thiacytidine
i.e. lamivudine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections
671911
Homo sapiens
UDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
-
-
?
2.7.1.74
UTP + 2'-deoxyadenosine
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
671911
Homo sapiens
UDP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.74
UTP + 2'-deoxycytidine
rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis
671911
Homo sapiens
UDP + 2'-deoxycytidine 5'-phosphate
-
-
-
?