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Literature summary extracted from

  • Jantschko, W.; Furtmueller, P.G.; Zederbauer, M.; Neugschwandtner, K.; Lehner, I.; Jakopitsch, C.; Arnhold, J.; Obinger, C.
    Exploitation of the unusual thermodynamic properties of human myeloperoxidase in inhibitor design (2005), Biochem. Pharmacol., 69, 1149-1157.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.11.2.2 medicine the enzyme is an interesting target for anti-inflammatory therapy Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.2.2 5-chlorotryptamine IC50: 0.00073 mM Homo sapiens
1.11.2.2 5-fluorotryptamine IC50: 0.00079 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.2.2 I- + H2O2 Homo sapiens myeloperoxidase plays a fundamental role in oxidant production by neutrophils ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.2.2 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.2.2 5-cyanoindole + H2O2
-
 Homo sapiens ?
-
 ?
1.11.2.2 5-hydroxytryptamine + H2O2
-
 Homo sapiens ?
-
 ?
1.11.2.2 5-nitroindole + H2O2
-
 Homo sapiens ?
-
 ?
1.11.2.2 I- + H2O2
-
 Homo sapiens ?
-
 ?
1.11.2.2 I- + H2O2 myeloperoxidase plays a fundamental role in oxidant production by neutrophils Homo sapiens ?
-
 ?
1.11.2.2 indole + H2O2
-
 Homo sapiens ?
-
 ?
1.11.2.2 tryptamine + H2O2
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.2.2 myeloperoxidase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.11.2.2 0.00073
-
 IC50: 0.00073 mM Homo sapiens 5-chlorotryptamine
1.11.2.2 0.00079
-
 IC50: 0.00079 mM Homo sapiens 5-fluorotryptamine