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Literature summary extracted from

  • Van den Neste, E.; Smal, C.; Cardoen, S.; Delacauw, A.; Frankard, J.; Ferrant, A.; Van den Berghe, G.; Bontemps, F.
    Activation of deoxycytidine kinase by UV-C-irradiation in chronic lymphocytic leukemia B-lymphocytes (2003), Biochem. Pharmacol., 65, 573-580.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.74 2-chloro-2'-deoxyadenosine
-
 Homo sapiens
2.7.1.74 aphidicolin
-
 Homo sapiens
2.7.1.74 etoposide
-
 Homo sapiens
2.7.1.74 additional information 2- to 3-fold activation of enzyme by UV-C light irradiation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.74 suramin no effect in unirradiated cells, complete abolishment of UV-C light induced activation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 ATP + 2'-deoxycytidine Homo sapiens involved in nucleotide synthesis, involved in DNA repair ADP + 2'-deoxycytidine 5'-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
 B-CLL patients
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.74 additional information a posttranslational modification is suggested to be responsible for the UV-C light irradiation induced activation of the enzyme activity Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 blood mononuclear cells used for experiments Homo sapiens
-
2.7.1.74 EHEB cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 ATP + 2'-deoxycytidine involved in nucleotide synthesis, involved in DNA repair Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.74 ATP
-
 Homo sapiens