BRENDA - Enzyme Database show

Activation of deoxycytidine kinase by UV-C-irradiation in chronic lymphocytic leukemia B-lymphocytes

Van den Neste, E.; Smal, C.; Cardoen, S.; Delacauw, A.; Frankard, J.; Ferrant, A.; Van den Berghe, G.; Bontemps, F.; Biochem. Pharmacol. 65, 573-580 (2003)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.74
2-chloro-2'-deoxyadenosine
-
Homo sapiens
2.7.1.74
aphidicolin
-
Homo sapiens
2.7.1.74
etoposide
-
Homo sapiens
2.7.1.74
additional information
2- to 3-fold activation of enzyme by UV-C light irradiation
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.74
suramin
no effect in unirradiated cells, complete abolishment of UV-C light induced activation
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
Homo sapiens
involved in nucleotide synthesis, involved in DNA repair
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Homo sapiens
-
B-CLL patients
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
2.7.1.74
additional information
a posttranslational modification is suggested to be responsible for the UV-C light irradiation induced activation of the enzyme activity
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
blood
mononuclear cells used for experiments
Homo sapiens
-
2.7.1.74
EHEB cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
671908
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + 2'-deoxycytidine
involved in nucleotide synthesis, involved in DNA repair
671908
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.74
2-chloro-2'-deoxyadenosine
-
Homo sapiens
2.7.1.74
aphidicolin
-
Homo sapiens
2.7.1.74
etoposide
-
Homo sapiens
2.7.1.74
additional information
2- to 3-fold activation of enzyme by UV-C light irradiation
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.74
suramin
no effect in unirradiated cells, complete abolishment of UV-C light induced activation
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
Homo sapiens
involved in nucleotide synthesis, involved in DNA repair
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
2.7.1.74
additional information
a posttranslational modification is suggested to be responsible for the UV-C light irradiation induced activation of the enzyme activity
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
blood
mononuclear cells used for experiments
Homo sapiens
-
2.7.1.74
EHEB cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
671908
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + 2'-deoxycytidine
involved in nucleotide synthesis, involved in DNA repair
671908
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?