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Literature summary extracted from

  • Xu, X.M.; Carlson, B.A.; Irons, R.; Mix, H.; Zhong, N.; Gladyshev, V.N.; Hatfield, D.L.
    Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis (2007), Biochem. J., 404, 115-120.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.9.3 DNA and amino acid sequence determination and analysis of SPS1 Mus musculus
2.7.9.3 DNA and amino acid sequence determination and analysis of SPS2, complementation of SPS2 knockout NIH3T3 cells by expression of SPS2 Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.9.3 additional information knockdown of SPS1 has no effect. Transfection of SPS1 into SPS2-knockdown cells cannot restore selenoprotein biosynthesis/SPS2 function Mus musculus
2.7.9.3 additional information knockdown of SPS2 in NIH3T3 cells using small interfering RNA results in severely impaired selenoprotein biosynthesis. Transfection of SPS2 into SPS2-knockdown cells restores selenoprotein biosynthesis, but expression of SPS1 cannot complement SPS2 function Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.9.3 additional information Mus musculus SPS1 probably has a specialized, non-essential role in selenoprotein metabolism ?
-
 ?
2.7.9.3 additional information Mus musculus SPS2 is essential for generating the selenium donor for selenocysteine biosynthesis in mammals ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.9.3 Mus musculus
-
-
-
2.7.9.3 Mus musculus P97364
-
-
2.7.9.3 Mus musculus Q8BH69
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.9.3 NIH-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.9.3 ATP + selenide + H2O
-
 Mus musculus AMP + selenophosphate + phosphate
-
 ?
2.7.9.3 additional information SPS1 probably has a specialized, non-essential role in selenoprotein metabolism Mus musculus ?
-
 ?
2.7.9.3 additional information SPS2 is essential for generating the selenium donor for selenocysteine biosynthesis in mammals Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.9.3 SelD
-
 Mus musculus
2.7.9.3 selenophosphate synthetase
-
 Mus musculus
2.7.9.3 selenophosphate synthetase 1
-
 Mus musculus
2.7.9.3 selenophosphate synthetase 2
-
 Mus musculus
2.7.9.3 SPS1
-
 Mus musculus
2.7.9.3 Sps2
-
 Mus musculus