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Literature summary extracted from

  • Yasuda, S.; Idell, S.; Liu, M.C.
    Generation and release of nitrotyrosine O-sulfate by HepG2 human hepatoma cells upon SIN-1 stimulation: identification of SULT1A3 as the enzyme responsible (2007), Biochem. J., 401, 497-503.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.1 morpholinosydnonimine i.e. SIN-1, a peroxynitrite generator, activates SULT1A3 in vivo in Hep-G2 cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.1 additional information
-
 additional information SULT1A3, kinetics and pH-dependence Homo sapiens
2.8.2.1 0.0065
-
 dopamine SULT1A3, pH 7.0, 37°C Homo sapiens
2.8.2.1 0.0316
-
 dopamine SULT1A3, pH 11.0, 37°C Homo sapiens
2.8.2.1 0.0381
-
 dopamine SULT1A3, pH 9.0, 37°C Homo sapiens
2.8.2.1 0.1305
-
 3-nitro-L-tyrosine SULT1A3, pH 7.0, 37°C Homo sapiens
2.8.2.1 0.1444
-
 3-nitro-L-tyrosine SULT1A3, pH 5.5, 37°C Homo sapiens
2.8.2.1 0.1641
-
 3-nitro-L-tyrosine SULT1A3, pH 9.0, 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 3-nitro-L-tyrosine Homo sapiens sulfation serves as a pathway for the metabolism/regulation of nitrotyrosine, nitrotyrosine O-sulfate is released into the medium of Hep-G2 hepatoma cells adenosine 3',5'-bisphosphate + 3-nitro-O4-sulfo-L-tyrosine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens P0DMM9 SULT1A3
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 Hep-G2 cell
-
 Homo sapiens
-
2.8.2.1 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.2.1 0.00001
-
 SULT1A3, substrate L-DOPA Homo sapiens
2.8.2.1 0.00085
-
 SULT1A3, substrate DL-3-hydroxyphenylalanine Homo sapiens
2.8.2.1 0.00206
-
 SULT1A3, substrate L-tyrosine Homo sapiens
2.8.2.1 0.00211
-
 SULT1A3, substrate 3-nitro-L-tyrosine Homo sapiens
2.8.2.1 0.01592
-
 SULT1A3, substrate dopamine Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 3-nitro-L-tyrosine sulfation serves as a pathway for the metabolism/regulation of nitrotyrosine, nitrotyrosine O-sulfate is released into the medium of Hep-G2 hepatoma cells Homo sapiens adenosine 3',5'-bisphosphate + 3-nitro-O4-sulfo-L-tyrosine
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 3-nitro-L-tyrosine specific reaction of SULT1A3, not performed by other SULT isozymes Homo sapiens adenosine 3',5'-bisphosphate + 3-nitro-O-sulfo-L-tyrosine
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + DL-3-hydroxyphenylalanine
-
 Homo sapiens adenosine 3',5'-bisphosphate + DL-3-(sulfooxy)phenylalanine
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + dopamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + dopamine sulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + L-DOPA
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + L-tyrosine low activity Homo sapiens adenosine 3',5'-bisphosphate + O-sulfo-L-tyrosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT1A3
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.1 6.5 10.5 SULT1A3, broad optimum with substrate dopamine Homo sapiens
2.8.2.1 7
-
 SULT1A3, with substrate 3-nitro-L-tyrosine Homo sapiens