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Literature summary extracted from
- Investigation of the mechanism of proton translocation by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria: does the enzyme operate by a Q-cycle mechanism? (2006), Biochem. J., 400, 541-550.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | Piericidin A | 0.0023 mM | Bos taurus |  |
| 7.1.1.2 | rotenone | 0.00025 mM | Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 7.1.1.2 | 0.0204 | - |
ubiquinone-2 | using 0.1 mM NADH at pH 7.5 | Bos taurus | |
| 7.1.1.2 | 0.024 | - |
decylubiquinone | using 0.1 mM NADH at pH 7.5 | Bos taurus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.1.1.2 | mitochondrion | the enzyme oxidizes NADH in the mitochondrial matrix and reduces ubiquinone in the inner mitochondrial membrane | Bos taurus | 5739 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | Fe-S | contains two [2Fe-2S] clusters and six [4Fe-4S] clusters | Bos taurus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.1.1.2 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 7.1.1.2 | Sephacryl S-300 gel-filtration | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.1.1.2 | heart | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.1.1.2 | NADH + decylubiquinone | - |
Bos taurus | NAD+ + decylubiquinol | - |
? | |
| 7.1.1.2 | NADH + ubiquinone-2 | - |
Bos taurus | NAD+ + ubiquinol-2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 7.1.1.2 | More | consists of 45 different subunits | Bos taurus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.1.1.2 | complex I | - |
Bos taurus |
| 7.1.1.2 | NADH:ubiquinone oxidoreductase | - |
Bos taurus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 7.1.1.2 | 6 | 9 | - |
Bos taurus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | FMN | - |
Bos taurus | |
| 7.1.1.2 | NADH | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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