Reference Id = 671878 - BRENDA Enzyme Database

Application

EC Number	Application	Comment	Organism
2.1.1.72	medicine	potential targets for both vaccines and antimicrobials	Tequatrovirus T4
2.1.1.72	medicine	potential targets for both vaccines and antimicrobials	Escherichia coli
2.1.1.72	medicine	potential targets for both vaccines and antimicrobials	Klebsiella pneumoniae
2.1.1.72	medicine	potential targets for both vaccines and antimicrobials	Streptococcus pneumoniae
2.1.1.72	medicine	potential targets for both vaccines and antimicrobials	Moraxella bovis
2.1.1.72	medicine	potential targets for both vaccines and antimicrobials	Cereibacter sphaeroides
2.1.1.72	medicine	potential targets for both vaccines and antimicrobials	Enterobacter cloacae
2.1.1.72	medicine	potential targets for both vaccines and antimicrobials	Caulobacter vibrioides
2.1.1.72	medicine	potential targets for both vaccines and antimicrobials	Thermus aquaticus

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
2.1.1.72	-	Tequatrovirus T4
2.1.1.72	-	Escherichia coli
2.1.1.72	-	Streptococcus pneumoniae
2.1.1.72	-	Moraxella bovis
2.1.1.72	-	Cereibacter sphaeroides
2.1.1.72	in complex with S-adenosyl-L-methionine, S-adenosyl-L-homocysteine and with the inhibitor sinefungin, at a resolution of 2.4 A	Thermus aquaticus

Protein Variants

EC Number	Protein Variants	Comment	Organism
2.1.1.72	additional information	site-directed mutagenesis at the dimer interface drastically affects enzyme activity in addition to the oligomeric status of the enzyme	Klebsiella pneumoniae

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.72	sinefungin	competetive inhibitor	Thermus aquaticus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism
2.1.1.72	0.0000036	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.0000174	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.0000255	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.00009	-	DNA adenine	-	Klebsiella pneumoniae
2.1.1.72	0.00009	-	DNA adenine	-	Streptococcus pneumoniae
2.1.1.72	0.00009	-	DNA adenine	-	Moraxella bovis
2.1.1.72	0.000091	-	DNA adenine	-	Enterobacter cloacae
2.1.1.72	0.000122	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.00015	-	DNA adenine	-	Klebsiella pneumoniae
2.1.1.72	0.00015	-	DNA adenine	-	Streptococcus pneumoniae
2.1.1.72	0.00015	-	DNA adenine	-	Moraxella bovis
2.1.1.72	0.000182	-	DNA adenine	-	Enterobacter cloacae
2.1.1.72	0.00027	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.0003	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.0006	-	DNA adenine	-	Thermus aquaticus
2.1.1.72	0.0008	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.00083	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.00091	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.001	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.0018	-	S-adenosyl-L-methionine	-	Enterobacter cloacae
2.1.1.72	0.00195	-	DNA adenine	-	Klebsiella pneumoniae
2.1.1.72	0.00195	-	DNA adenine	-	Streptococcus pneumoniae
2.1.1.72	0.00195	-	DNA adenine	-	Moraxella bovis
2.1.1.72	0.0037	-	S-adenosyl-L-methionine	-	Thermus aquaticus
2.1.1.72	0.0056	-	S-adenosyl-L-methionine	-	Escherichia coli
2.1.1.72	0.0071	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.0122	-	S-adenosyl-L-methionine	-	Escherichia coli

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.72	Caulobacter vibrioides	-	-	-
2.1.1.72	Cereibacter sphaeroides	P14751	-	-
2.1.1.72	Enterobacter cloacae	-	-	-
2.1.1.72	Escherichia coli	-	-	-
2.1.1.72	Klebsiella pneumoniae	-	-	-
2.1.1.72	Moraxella bovis	P23192	-	-
2.1.1.72	Streptococcus pneumoniae	P04043	-	-
2.1.1.72	Tequatrovirus T4	P04392	-	-
2.1.1.72	Thermus aquaticus	P14385	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
2.1.1.72	S-adenosyl-L-methionine + DNA adenine	-	Tequatrovirus T4	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
2.1.1.72	S-adenosyl-L-methionine + DNA adenine	-	Klebsiella pneumoniae	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
2.1.1.72	S-adenosyl-L-methionine + DNA adenine	-	Streptococcus pneumoniae	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
2.1.1.72	S-adenosyl-L-methionine + DNA adenine	-	Moraxella bovis	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
2.1.1.72	S-adenosyl-L-methionine + DNA adenine	-	Cereibacter sphaeroides	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
2.1.1.72	S-adenosyl-L-methionine + DNA adenine	-	Enterobacter cloacae	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
2.1.1.72	S-adenosyl-L-methionine + DNA adenine	-	Caulobacter vibrioides	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
2.1.1.72	S-adenosyl-L-methionine + DNA adenine	-	Thermus aquaticus	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?
2.1.1.72	S-adenosyl-L-methionine + DNA adenine	-	Escherichia coli	S-adenosyl-L-homocysteine + DNA 6-methyladenine	-	?

Subunits

EC Number	Subunits	Comment	Organism
2.1.1.72	dimer	-	Tequatrovirus T4
2.1.1.72	dimer	-	Klebsiella pneumoniae
2.1.1.72	dimer	-	Moraxella bovis
2.1.1.72	dimer	-	Escherichia coli
2.1.1.72	dimer	dimerizes at high protein concentrations	Cereibacter sphaeroides
2.1.1.72	dimer	in solution, but dissociate into monomers upon addition of the DNA	Caulobacter vibrioides

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.72	CcrM	-	Caulobacter vibrioides
2.1.1.72	Dam	-	Tequatrovirus T4
2.1.1.72	Dam	-	Escherichia coli
2.1.1.72	Dam	-	Klebsiella pneumoniae
2.1.1.72	Dam	-	Streptococcus pneumoniae
2.1.1.72	Dam	-	Moraxella bovis
2.1.1.72	Dam	-	Cereibacter sphaeroides
2.1.1.72	Dam	-	Enterobacter cloacae
2.1.1.72	Dam	-	Caulobacter vibrioides
2.1.1.72	Dam	-	Thermus aquaticus
2.1.1.72	DNA adenine MTase	-	Tequatrovirus T4
2.1.1.72	DNA adenine MTase	-	Escherichia coli
2.1.1.72	DNA adenine MTase	-	Klebsiella pneumoniae
2.1.1.72	DNA adenine MTase	-	Streptococcus pneumoniae
2.1.1.72	DNA adenine MTase	-	Moraxella bovis
2.1.1.72	DNA adenine MTase	-	Cereibacter sphaeroides
2.1.1.72	DNA adenine MTase	-	Enterobacter cloacae
2.1.1.72	DNA adenine MTase	-	Caulobacter vibrioides
2.1.1.72	DNA adenine MTase	-	Thermus aquaticus
2.1.1.72	EcoDam	-	Escherichia coli
2.1.1.72	M.DpnM	-	Streptococcus pneumoniae
2.1.1.72	M.EcaI	-	Enterobacter cloacae
2.1.1.72	M.EcoP15I	-	Escherichia coli
2.1.1.72	M.EcoRI	-	Escherichia coli
2.1.1.72	M.EcoRV	-	Escherichia coli
2.1.1.72	M.KpnI	-	Klebsiella pneumoniae
2.1.1.72	M.MboIIA	-	Moraxella bovis
2.1.1.72	M.RsrI	-	Cereibacter sphaeroides
2.1.1.72	M.TaqI	-	Thermus aquaticus
2.1.1.72	N6-adenine MTase	-	Tequatrovirus T4
2.1.1.72	N6-adenine MTase	-	Escherichia coli
2.1.1.72	N6-adenine MTase	-	Klebsiella pneumoniae
2.1.1.72	N6-adenine MTase	-	Streptococcus pneumoniae
2.1.1.72	N6-adenine MTase	-	Moraxella bovis
2.1.1.72	N6-adenine MTase	-	Cereibacter sphaeroides
2.1.1.72	N6-adenine MTase	-	Enterobacter cloacae
2.1.1.72	N6-adenine MTase	-	Caulobacter vibrioides
2.1.1.72	N6-adenine MTase	-	Thermus aquaticus
2.1.1.72	T4 Dam	-	Tequatrovirus T4

Turnover Number [1/s]

EC Number	Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism
2.1.1.72	0.000096	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.000118	-	S-adenosyl-L-methionine	-	Escherichia coli
2.1.1.72	0.00021	-	S-adenosyl-L-methionine	-	Escherichia coli
2.1.1.72	0.000248	-	S-adenosyl-L-methionine	-	Escherichia coli
2.1.1.72	0.00028	-	S-adenosyl-L-methionine	-	Escherichia coli
2.1.1.72	0.00033	-	DNA adenine	-	Klebsiella pneumoniae
2.1.1.72	0.00033	-	DNA adenine	-	Streptococcus pneumoniae
2.1.1.72	0.00033	-	DNA adenine	-	Moraxella bovis
2.1.1.72	0.00072	-	DNA adenine	-	Klebsiella pneumoniae
2.1.1.72	0.00072	-	DNA adenine	-	Streptococcus pneumoniae
2.1.1.72	0.00072	-	DNA adenine	-	Moraxella bovis
2.1.1.72	0.00117	-	S-adenosyl-L-methionine	-	Escherichia coli
2.1.1.72	0.0022	-	DNA adenine	-	Klebsiella pneumoniae
2.1.1.72	0.0022	-	DNA adenine	-	Streptococcus pneumoniae
2.1.1.72	0.0022	-	DNA adenine	-	Moraxella bovis
2.1.1.72	0.0025	-	DNA adenine	-	Enterobacter cloacae
2.1.1.72	0.0041	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.0047	-	DNA adenine	-	Enterobacter cloacae
2.1.1.72	0.0053	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.0056	-	DNA adenine	-	Klebsiella pneumoniae
2.1.1.72	0.0056	-	DNA adenine	-	Streptococcus pneumoniae
2.1.1.72	0.0056	-	DNA adenine	-	Moraxella bovis
2.1.1.72	0.0056	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.019	-	DNA adenine	-	Cereibacter sphaeroides
2.1.1.72	0.0208	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.094	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.105	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.11	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.124	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.14	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.142	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.16	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.167	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.203	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.23	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.25	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.27	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.3	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.316	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.33	-	DNA adenine	-	Caulobacter vibrioides
2.1.1.72	0.37	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.447	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.58	-	DNA adenine	-	Escherichia coli
2.1.1.72	0.73	-	DNA adenine	-	Thermus aquaticus
2.1.1.72	0.93	-	DNA adenine	-	Escherichia coli

Literature summary extracted from

Application

Crystallization (Commentary)

Protein Variants

Inhibitors

KM Value [mM]

Organism

Substrates and Products (Substrate)

Subunits

Synonyms

Turnover Number [1/s]