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Literature summary extracted from

  • Lanthier, J.; Desrosiers, R.R.
    Regulation of protein L-isoaspartyl methyltransferase by cell-matrix interactions: involvement of integrin alphavbeta3, PI 3-kinase, and the proteasome (2006), Biochem. Cell Biol., 84, 684-694.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.77 additional information Bos taurus PIMT level is downregulated by proteasomal degradation, involving the PI3K pathway, during cell attachment. The regulation of PIMT level upon cell-substratum contact suggests a potential role for PIMT in biological processes such as wound healing, cell migration, and tumor metastasis dissemination ?
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Organism

EC Number Organism UniProt Comment Textmining
2.1.1.77 Bos taurus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.77 aortic endothelium PIMT expression in bovine aortic endothelial cells is regulated by cell detachment and readhesion to a substratum Bos taurus
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2.1.1.77 carcinoma cell PIMT levels are regulated by cell adhesion in various cancer cell lines. The upregulation of PIMT expression could be prevented by an anti-alphavbeta3 antibody (LM609) or by a cyclic RGD peptide (XJ735) specific to integrin alphavbeta3. PIMT expression returns to the basal level when cells are replated on a substratum after detachment, though downregulation of PIMT expression could be partly prevented by the PI3K inhibitors LY294002 and wortmannin, as well as by the proteasome inhibitors MG-132, lactacystin, and beta-lactone Bos taurus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.77 additional information PIMT level is downregulated by proteasomal degradation, involving the PI3K pathway, during cell attachment. The regulation of PIMT level upon cell-substratum contact suggests a potential role for PIMT in biological processes such as wound healing, cell migration, and tumor metastasis dissemination Bos taurus ?
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Synonyms

EC Number Synonyms Comment Organism
2.1.1.77 PIMT
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 Bos taurus