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Literature summary extracted from

  • Robison, A.J.; Winder, D.G.; Colbran, R.J.; Bartlett, R.K.
    Oxidation of calmodulin alters activation and regulation of CaMKII (2007), Biochem. Biophys. Res. Commun., 356, 97-101.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on, activating activity is abolished by calmodulin oxidation, phosphorylation of substrate by CaMKII and CaMKII autophosphorylation at Thr286, calmodulin binding to the enzyme inhibits autophosphorylation at Thr305/Thr306, which leads to enzyme inhibition, overview Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on, activates phosphorylation of substrate by CaMKII and CaMKII autophosphorylation at Thr286 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 phosphoprotein the enzyme performs autophosphorylation at Thr286, activating the enzyme, and at Thr305/Thr306 of the calmodulin binding site inhibiting the enzyme Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain
-
 Rattus norvegicus
-
2.7.11.17 forebrain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 additional information the enzyme performs autophosphorylation at Thr286 activating the enzyme activity, and at Thr305/Thr306, which inhibits calmodulin binding and enzyme activation Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 CaMKII
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Rattus norvegicus