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Literature summary extracted from

  • Fujita, A.; Sato, C.; Kitajima, K.
    Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase (2007), Biochem. Biophys. Res. Commun., 355, 174-180.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.43 expressed in CHO cells, HeLa cells, and NIH-3T3 cells Mus musculus
2.7.7.43 expression in CHO cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.43 DELTA408-424 deletion mutant devoid of the second putative nuclear export signal, by immunofluorescent microscopy it is shown that this deletion mutant has an increased nuclear localisation combined with a decreased cytoplasmic localisation Mus musculus
2.7.7.43 DELTA61-69 deletion mutant devoid of the first putative nuclear export signal, by immunofluorescent microscopy it is shown that is deletion mutant has an increased nuclear localisation combined with a decreased cytoplasmic localisation Mus musculus
2.7.7.43 additional information by deletion mutant analysis it is demonstrated that mouse CSS contains two nuclear export signals which regulate the transport of the protein from nucleus towards cytosol Mus musculus
2.7.7.43 additional information the two nuclear export signals of mouse CSS are conserved among mammals and fish CSSs but they are not present in bacteria or insect CSS Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.43 cytoplasm
-
 Mus musculus 5737
-
2.7.7.43 cytoplasm a small, but significant population of the mouse CMP-sialic acid synthetase is also present in cytoplasm Mus musculus 5737
-
2.7.7.43 nucleus vertebrate CSS are usually localised in the nucleus due to a nuclear localisation signal, however in mouse a small proportion of CSS is also present in cytoplasm due to two nuclear export signals Mus musculus 5634
-
2.7.7.43 nucleus mostly localized in nucleus Mus musculus 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.43 Mus musculus Q99KK2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.43 CTP + N-acylneuraminate
-
 Mus musculus diphosphate + CMP-N-acylneuraminate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.43 CMP-sialic acid synthetase
-
 Mus musculus
2.7.7.43 CSS
-
 Mus musculus
2.7.7.43 mCSS
-
 Mus musculus