EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.14.18 | expressed in Escherichia coli | Rattus norvegicus |
1.14.14.18 | expression in rat basophilic leukemia RBL-2H3 cells | Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.14.14.18 | additional information | rat HO-1 cDNA transfected RBL-2H3 cells show altered cytokine production in response to stimulation with anti-ovalbumin OA serum/OA compared to Mock transfected RBL-2H3 cells. HO-1 inhibits anti-OA serum/OA-induced IL-3 and TNF-alpha production. Inhibition of HO-1 activity by Zn (II) protoporphyrin IX, a specific HO-1 inhibitor, prevents the suppression of TNF-alpha production. The cytokine inhibition by HO-1 is associated with selective suppression of the DNA-binding activity of AP-1 transcription factors, phenotype, overview | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.18 | Zn (II) protoporphyrin IX | a specific HO-1 inhibitor, inhibition of HO-1 activity by Zn (II) protoporphyrin IX, a specific HO-1 inhibitor, prevents the suppression of TNF-alpha production. The cytokine inhibition by HO-1 is associated with selective suppression of the DNA-binding activity of AP-1 transcription factors | Rattus norvegicus | |
1.14.14.18 | Zn(II) protoporphyrin IX | 0.02 mM, potent inhibitor | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.18 | additional information | Rattus norvegicus | HO-1 is involved in host defense reactions against various stresses, HO-1 modulates immunocyte activation and functions and suppresses mast cell degranulation, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.18 | Rattus norvegicus | - |
- |
- |
1.14.14.18 | Rattus norvegicus | P06762 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.18 | basophilic leukemia cell line | - |
Rattus norvegicus | - |
1.14.14.18 | RBL-2H3 cell | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.18 | heme + electron donor + O2 | - |
Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
1.14.14.18 | additional information | HO-1 is involved in host defense reactions against various stresses, HO-1 modulates immunocyte activation and functions and suppresses mast cell degranulation, overview | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.18 | heme oxygenase-1 | - |
Rattus norvegicus |
1.14.14.18 | HO-1 | - |
Rattus norvegicus |