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Literature summary extracted from

  • Graf, C.; Rovina, P.; Tauzin, L.; Schanzer, A.; Bornancin, F.
    Enhanced ceramide-induced apoptosis in ceramide kinase overexpressing cells (2007), Biochem. Biophys. Res. Commun., 354, 309-314.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.138 expressed in COS-1 cells Homo sapiens
2.7.1.138 expressed in COS-1 fibroblasts and RBL-2H3 basophils Homo sapiens
2.7.1.138 expression in Escherichia coli, overexpression of human CerK in COS-1 and RBL-2H3 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.138 cell membrane
-
 Homo sapiens
-
-
2.7.1.138 Golgi apparatus
-
 Homo sapiens 5794
-
2.7.1.138 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ceramide + ATP Homo sapiens CERK plays a role in cell signalling ceramide 1-phosphate + ADP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Homo sapiens
-
-
-
2.7.1.138 Homo sapiens Q8TCT0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.138 basophil
-
 Homo sapiens
-
2.7.1.138 fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 ATP + ceramide
-
 Homo sapiens ADP + ceramide 1-phosphate
-
 ?
2.7.1.138 C16-ceramide + ATP
-
 Homo sapiens C16-ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 C2-ceramide + ATP
-
 Homo sapiens C2-ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 C8-ceramide + ATP
-
 Homo sapiens C8-ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 ceramide + ATP
-
 Homo sapiens ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 ceramide + ATP CERK plays a role in cell signalling Homo sapiens ceramide 1-phosphate + ADP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 CERK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.138 ATP
-
 Homo sapiens