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Literature summary extracted from
- Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated L-tryptophan metabolism (2005), Biochem. Biophys. Res. Commun., 338, 12-19.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.52 | additional information | Homo sapiens | the enzyme plays an important physiological role in the defense mechanism against a variety of infectious pathogens, in the regulation of T-cell function by macrophages and a subset of dendritic cells, and in the synthesis of UV filters in human lenses. Serious problems arise from the unregulated over-expression of the enzyme, which often results in a deleterious systemic Trp depletion and/or the accumulation of neurotoxin, quinolinic acidn the brain. Enzyme expression in malignant tumors helps them to avoid the immune surveillance through a local Trp depletion. The kynurenilation of the lens protein with UV filters thus appears to be the major cause of age-related cataract | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.52 | Homo sapiens | - |
- |
- |
| 1.13.11.52 | Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.13.11.52 | brain | - |
Oryctolagus cuniculus | - |
| 1.13.11.52 | colon | - |
Oryctolagus cuniculus | - |
| 1.13.11.52 | intestine | - |
Homo sapiens | - |
| 1.13.11.52 | kidney | - |
Oryctolagus cuniculus | - |
| 1.13.11.52 | large intestine | - |
Oryctolagus cuniculus | - |
| 1.13.11.52 | lung | - |
Homo sapiens | - |
| 1.13.11.52 | lung | - |
Oryctolagus cuniculus | - |
| 1.13.11.52 | placenta | term placenta | Homo sapiens | - |
| 1.13.11.52 | small intestine | - |
Oryctolagus cuniculus | - |
| 1.13.11.52 | spleen | - |
Oryctolagus cuniculus | - |
| 1.13.11.52 | stomach | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.52 | D-Trp + O2 | - |
Homo sapiens | D-formylkynurenine | - |
? | |
| 1.13.11.52 | D-Trp + O2 | - |
Oryctolagus cuniculus | D-formylkynurenine | - |
? | |
| 1.13.11.52 | L-Trp + O2 | - |
Homo sapiens | L-formylkynurenine | - |
? | |
| 1.13.11.52 | L-Trp + O2 | - |
Oryctolagus cuniculus | L-formylkynurenine | - |
? | |
| 1.13.11.52 | additional information | the enzyme plays an important physiological role in the defense mechanism against a variety of infectious pathogens, in the regulation of T-cell function by macrophages and a subset of dendritic cells, and in the synthesis of UV filters in human lenses. Serious problems arise from the unregulated over-expression of the enzyme, which often results in a deleterious systemic Trp depletion and/or the accumulation of neurotoxin, quinolinic acidn the brain. Enzyme expression in malignant tumors helps them to avoid the immune surveillance through a local Trp depletion. The kynurenilation of the lens protein with UV filters thus appears to be the major cause of age-related cataract | Homo sapiens | ? | - |
? | |
| 1.13.11.52 | serotonin + O2 | - |
Homo sapiens | ? | - |
? | |
| 1.13.11.52 | serotonin + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.13.11.52 | tryptamine + O2 | - |
Homo sapiens | ? | - |
? | |
| 1.13.11.52 | tryptamine + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.13.11.52 | IDO | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.52 | heme | - |
Homo sapiens | |
| 1.13.11.52 | heme | - |
Oryctolagus cuniculus | |
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