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Literature summary extracted from

  • Wang, J.; Yu, L.; Schmidt, R.E.; Su, C.; Huang, X.; Gould, K.; Cao, G.
    Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates (2005), Biochem. Biophys. Res. Commun., 332, 735-742.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.1 hSCD1 and GFP-hSCD1 expressed in HEK-293 cells Homo sapiens
1.14.19.1 hSCD5 and GFP-fused hSCD5 expressed in HEK-293 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.1 endoplasmic reticulum membrane hSCD1 fused to GFP and expressed in HEK-293 cells Homo sapiens 5789
-
1.14.19.1 endoplasmic reticulum membrane hSCD5 fused to GFP and expressed in HEK-293 cells Homo sapiens 5789
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.19.1 58000
-
 hSCD 5 fused to GFP, immunoblot with anti-GFP antibody Homo sapiens
1.14.19.1 58000
-
 hSCD1 fused to GFP, immunoblot with anti-GFP antibody Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Homo sapiens
-
 hSCD1 cloned from a human liver cDNA library
-
1.14.19.1 Homo sapiens Q86SK9 hSCD5 cloned from a human brain cDNA library
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 adipose tissue hSCD1, sevenfold higher mRNA level in adipose tissue than in liver, real-time PCR Homo sapiens
-
1.14.19.1 brain equivalent levels of hSCD1 and hSCD5 mRNA in adult brain, real-time PCR Homo sapiens
-
1.14.19.1 liver hSCD1, sevenfold higher mRNA level in adipose tissue than in liver, real-time PCR Homo sapiens
-
1.14.19.1 lung hSCD1 mRNA, real-time PCR Homo sapiens
-
1.14.19.1 pancreas hSCD5 mRNA in adult pancreas, real-time PCR Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.19.1 additional information
-
 14C-labeled steaoryl-CoA as substrate, microsomal fraction, similar desaturase activity of hSCD5 and GFP-hSCD5, thin layer chromatography Homo sapiens
1.14.19.1 additional information
-
 14C-labeled stearoyl-CoA as substrate, microsomal fraction, similar desaturase activity of hSCD1 and GFP-hSCD1, thin layer chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 stearoyl-CoA + AH2 + O2
-
 Homo sapiens oleoyl-CoA + A + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 hSCD1
-
 Homo sapiens
1.14.19.1 hSCD5
-
 Homo sapiens