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Literature summary extracted from

  • Levine, S.M.; Raben, N.; Xie, D.; Askin, F.B.; Tuder, R.; Mullins, M.; Rosen, A.; Casciola-Rosen, L.A.
    Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis (2007), Arthritis Rheum., 56, 2729-2739.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
6.1.1.21 D48A site-directed mutagenesis, the mutant is cleaved by caspase-6, but not by granzyme B Homo sapiens
6.1.1.21 additional information HisRS granzyme B site mapping using site-directed mutagenesis Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.21 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.21 ATP + L-histidine + tRNAHis Homo sapiens strong association of autoantibodies, specificity recognizing the enzyme's granzyme B binding site of the lung enzyme, to HisRS with interstitial lung disease in patients with myositis AMP + diphosphate + L-histidinyl-tRNAHis
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.21 Homo sapiens
-
 Jo-1-positive patients with myositis
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
6.1.1.21 proteolytic modification lung HisRS cleavage by the cytotoxic lymphocyte serine protease granzyme B in vitro at LGPD48, caspase 6, which shares a tetrapeptide specificity similar to that of granzyme B, cleaves HisRS, producing a fragment of similar size, but cleavage sites are nonoverlapping Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.21 lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.21 ATP + L-histidine + tRNAHis
-
 Homo sapiens AMP + diphosphate + L-histidinyl-tRNAHis
-
 ?
6.1.1.21 ATP + L-histidine + tRNAHis strong association of autoantibodies, specificity recognizing the enzyme's granzyme B binding site of the lung enzyme, to HisRS with interstitial lung disease in patients with myositis Homo sapiens AMP + diphosphate + L-histidinyl-tRNAHis
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.21 HisRS
-
 Homo sapiens
6.1.1.21 histidyl-transfer RNA synthetase
-
 Homo sapiens
6.1.1.21 Jo-1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.21 ATP
-
 Homo sapiens