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Literature summary extracted from

  • Dat, N.T.; Cai, X.F.; Rho, M.C.; Lee, H.S.; Bae, K.; Kim, Y.H.
    The inhibition of diacylglycerol acyltransferase by terpenoids from Youngia koidzumiana (2005), Arch. Pharm. Res., 28, 164-168.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.20 (2alpha,3beta)-2,3-dihydroxyurs-12-en-28-oic acid IC50: 0.0443 mM Rattus norvegicus
2.3.1.20 brachynereolide IC50: 0.25 mM, above Rattus norvegicus
2.3.1.20 crepidiaside C IC50: 0.25 mM, above Rattus norvegicus
2.3.1.20 cryptotanshinone IC50: 0.0273 mM Rattus norvegicus
2.3.1.20 germanicol acetate IC50: 0.25 mM, above Rattus norvegicus
2.3.1.20 ixerin Y IC50: 0.25 mM, above Rattus norvegicus
2.3.1.20 methyl ursolate IC50: 0.0264 mM Rattus norvegicus
2.3.1.20 additional information an ethylacetic extract of Youngia koidzumiana, a plant endemic to the Mount Chiri region of Korea, significantly inhibits the liver microsome enzyme Rattus norvegicus
2.3.1.20 oleanolic acid IC50: 0.0317 mM Rattus norvegicus
2.3.1.20 sesquiterpenoids weak inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.20 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.20 Mg2+
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.20 Rattus norvegicus
-
-
-
2.3.1.20 Rattus norvegicus
-
 male sprague-dawley rats
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.20 native enzyme partially by microsome preparation Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.20 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.20 1,2-dioleoyl-sn-glycerol + palmitoyl-CoA
-
 Rattus norvegicus 1,2-dioleoyl-3-palmitoyl-sn-glycerol + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.20 DGAT
-
 Rattus norvegicus
2.3.1.20 diacylglycerol acyltransferase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.20 25
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.20 8
-
 assay at Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.20 0.0264
-
 IC50: 0.0264 mM Rattus norvegicus methyl ursolate
2.3.1.20 0.0273
-
 IC50: 0.0273 mM Rattus norvegicus cryptotanshinone
2.3.1.20 0.0317
-
 IC50: 0.0317 mM Rattus norvegicus oleanolic acid
2.3.1.20 0.0443
-
 IC50: 0.0443 mM Rattus norvegicus (2alpha,3beta)-2,3-dihydroxyurs-12-en-28-oic acid
2.3.1.20 0.25
-
 IC50: 0.25 mM, above Rattus norvegicus brachynereolide
2.3.1.20 0.25
-
 IC50: 0.25 mM, above Rattus norvegicus ixerin Y
2.3.1.20 0.25
-
 IC50: 0.25 mM, above Rattus norvegicus crepidiaside C
2.3.1.20 0.25
-
 IC50: 0.25 mM, above Rattus norvegicus germanicol acetate