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Literature summary extracted from
- Structural analogues of reactive intermediates as inhibitors of glucosamine-6-phosphate synthase and phosphoglucose isomerase (2006), Arch. Biochem. Biophys., 450, 39-49.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 2.6.1.16 | expressed in Saccharomyces cerevisiae strain YRS C-65 | Candida albicans |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.6.1.16 | 2-amino-2-deoxy-D-glucitol-6-phosphate | - |
Candida albicans |  |
| 2.6.1.16 | 2-amino-2-deoxy-D-glucitol-6-phosphate dimethyl ester | - |
Candida albicans | |
| 2.6.1.16 | 2-amino-2-deoxy-D-mannitol-6-phosphate | - |
Candida albicans | |
| 2.6.1.16 | 5-phospho-D-arabinoamide | - |
Candida albicans | |
| 2.6.1.16 | N-acetyl-2-amino-2-deoxy-D-glucitol-6-phosphate | - |
Candida albicans | |
| 5.3.1.9 | 2-amino-2-deoxy-D-glucitol 6-phosphate | comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase | Saccharomyces cerevisiae | |
| 5.3.1.9 | 2-amino-2-deoxy-D-glucitol 6-phosphate dimethyl ester | comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase | Saccharomyces cerevisiae | |
| 5.3.1.9 | 2-amino-2-deoxy-D-mannitol 6-phosphate | comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase | Saccharomyces cerevisiae | |
| 5.3.1.9 | 2-Deoxy-D-glucitol 6-phosphate | comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase | Saccharomyces cerevisiae | |
| 5.3.1.9 | 5-phospho-D-arabinoamide | comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase | Saccharomyces cerevisiae | |
| 5.3.1.9 | 5-phospho-D-arabinoate | comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase | Saccharomyces cerevisiae | |
| 5.3.1.9 | 5-phospho-D-arabinohydroxamate | comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase | Saccharomyces cerevisiae | |
| 5.3.1.9 | 6-phospho-D-gluconate | comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase | Saccharomyces cerevisiae | |
| 5.3.1.9 | 6-phospho-D-gluconoamide | comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase | Saccharomyces cerevisiae | |
| 5.3.1.9 | D-glucitol 6-phosphate | comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase | Saccharomyces cerevisiae | |
| 5.3.1.9 | N-acetyl-2-amino-2-deoxy-D-glucitol 6-phosphate | comparison with inhibition of Candida albicans D-glucosamine 6-phosphate synthase | Saccharomyces cerevisiae | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.6.1.16 | Candida albicans | - |
- |
- |
| 5.3.1.9 | Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 2.6.1.16 | - |
Candida albicans |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.6.1.16 | L-glutamine + D-fructose 6-phosphate | - |
Candida albicans | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| 5.3.1.9 | D-fructose 6-phosphate | - |
Saccharomyces cerevisiae | D-glucose 6-phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.6.1.16 | GlcN-6-P synthase | - |
Candida albicans |
| 2.6.1.16 | glucosamine-6-phosphate synthase | - |
Candida albicans |
| 2.6.1.16 | L-glutamine:D-fructose-6-phosphate amidotransferase (hexose isomerizing) | - |
Candida albicans |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.6.1.16 | 0.009 | - |
2-amino-2-deoxy-D-mannitol-6-phosphate | - |
Candida albicans | |
| 2.6.1.16 | 0.035 | - |
2-amino-2-deoxy-D-glucitol-6-phosphate | - |
Candida albicans | |
| 2.6.1.16 | 0.62 | - |
5-phospho-D-arabinoamide | - |
Candida albicans | |
| 2.6.1.16 | 0.68 | - |
2-amino-2-deoxy-D-glucitol-6-phosphate dimethyl ester | - |
Candida albicans | |
| 2.6.1.16 | 0.84 | - |
N-acetyl-2-amino-2-deoxy-D-glucitol-6-phosphate | - |
Candida albicans | |
| 5.3.1.9 | 0.0022 | - |
5-phospho-D-arabinoate | pH 8.0 | Saccharomyces cerevisiae | |
| 5.3.1.9 | 0.0046 | - |
5-phospho-D-arabinoamide | pH 8.0 | Saccharomyces cerevisiae | |
| 5.3.1.9 | 0.04 | - |
D-glucitol 6-phosphate | pH 8.0 | Saccharomyces cerevisiae | |
| 5.3.1.9 | 0.076 | - |
N-acetyl-2-amino-2-deoxy-D-glucitol 6-phosphate | pH 8.0 | Saccharomyces cerevisiae | |
| 5.3.1.9 | 0.148 | - |
6-phospho-D-gluconate | pH 8.0 | Saccharomyces cerevisiae | |
| 5.3.1.9 | 0.56 | - |
6-phospho-D-gluconoamide | pH 8.0 | Saccharomyces cerevisiae | |
| 5.3.1.9 | 0.68 | - |
2-Deoxy-D-glucitol 6-phosphate | pH 8.0 | Saccharomyces cerevisiae | |
| 5.3.1.9 | 12.3 | - |
2-amino-2-deoxy-D-glucitol 6-phosphate | pH 8.0 | Saccharomyces cerevisiae | |
| 5.3.1.9 | 17.2 | - |
2-amino-2-deoxy-D-mannitol 6-phosphate | pH 8.0 | Saccharomyces cerevisiae | |
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