EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.1.74 | medicine | human pathogen, target for new antibiotics | Geobacillus stearothermophilus |
2.1.1.74 | medicine | human pathogen, target for new antibiotics | Mycobacterium leprae |
2.1.1.74 | medicine | human pathogen, target for new antibiotics | Mycobacterium tuberculosis |
2.1.1.74 | medicine | human pathogen, target for new antibiotics | Clostridium acidi-urici |
2.1.1.74 | medicine | human pathogen, target for new antibiotics | Clostridium botulinum |
2.1.1.74 | medicine | human pathogen, target for new antibiotics | Rickettsia sp. |
2.1.1.74 | medicine | human pathogen, target for new antibiotics | Bacillus anthracis |
2.1.1.74 | medicine | human pathogen, target for new antibiotics | Treponema palladium |
2.1.1.148 | additional information | residues His53, Glu190, Arg90, and Arg182 are essential for TS activity | Paramecium bursaria Chlorella virus-1 |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.1.1.148 | - |
Mycobacterium tuberculosis |
2.1.1.148 | crystal structure shows certain small structural differences in the active site when compared with either bacterial FDTS | Paramecium bursaria Chlorella virus-1 |
2.1.1.148 | crystal structure shows no structural similarity with classical TS | Thermotoga maritima |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.148 | additional information | 5-fluorouracil is not a potential inhibitor | Paramecium bursaria Chlorella virus-1 | |
2.1.1.148 | NADPH | inhibits FDTS at high concentrations at all temperatures, NADPH may not be the natural reducing agent of FDTS | Thermotoga maritima |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.74 | Bacillus anthracis | - |
- |
- |
2.1.1.74 | Clostridium acidi-urici | - |
- |
- |
2.1.1.74 | Clostridium botulinum | - |
- |
- |
2.1.1.74 | Geobacillus stearothermophilus | - |
- |
- |
2.1.1.74 | Mycobacterium leprae | - |
- |
- |
2.1.1.74 | Mycobacterium tuberculosis | - |
- |
- |
2.1.1.74 | Rickettsia sp. | - |
- |
- |
2.1.1.74 | Treponema palladium | - |
- |
- |
2.1.1.148 | Bacillus anthracis | - |
- |
- |
2.1.1.148 | Chlamydia trachomatis | - |
- |
- |
2.1.1.148 | Clostridium botulinum | - |
- |
- |
2.1.1.148 | Helicobacter pylori | - |
- |
- |
2.1.1.148 | Mycobacterium leprae | - |
- |
- |
2.1.1.148 | Mycobacterium tuberculosis | P9WG57 | - |
- |
2.1.1.148 | Mycobacterium tuberculosis H37Rv | P9WG57 | - |
- |
2.1.1.148 | no activity in Homo sapiens | - |
- |
- |
2.1.1.148 | Paramecium bursaria Chlorella virus-1 | - |
- |
- |
2.1.1.148 | Pyrococcus furiosus | - |
- |
- |
2.1.1.148 | Rickettsia sp. | - |
- |
- |
2.1.1.148 | Thermotoga maritima | - |
- |
- |
2.1.1.148 | Treponema palladium | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.74 | 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | - |
Geobacillus stearothermophilus | tetrahydrofolate + tRNA TpsiC + FAD | - |
? | |
2.1.1.74 | 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | - |
Mycobacterium leprae | tetrahydrofolate + tRNA TpsiC + FAD | - |
? | |
2.1.1.74 | 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | - |
Mycobacterium tuberculosis | tetrahydrofolate + tRNA TpsiC + FAD | - |
? | |
2.1.1.74 | 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | - |
Clostridium acidi-urici | tetrahydrofolate + tRNA TpsiC + FAD | - |
? | |
2.1.1.74 | 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | - |
Clostridium botulinum | tetrahydrofolate + tRNA TpsiC + FAD | - |
? | |
2.1.1.74 | 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | - |
Rickettsia sp. | tetrahydrofolate + tRNA TpsiC + FAD | - |
? | |
2.1.1.74 | 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | - |
Bacillus anthracis | tetrahydrofolate + tRNA TpsiC + FAD | - |
? | |
2.1.1.74 | 5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2 | - |
Treponema palladium | tetrahydrofolate + tRNA TpsiC + FAD | - |
? | |
2.1.1.148 | 5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Chlamydia trachomatis | dTMP + tetrahydrofolate + FAD | - |
? | |
2.1.1.148 | 5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Helicobacter pylori | dTMP + tetrahydrofolate + FAD | - |
? | |
2.1.1.148 | additional information | mRNA binding traits | Pyrococcus furiosus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.1.148 | tetramer | - |
Thermotoga maritima |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.74 | FDRTS | - |
Geobacillus stearothermophilus |
2.1.1.74 | FDRTS | - |
Mycobacterium leprae |
2.1.1.74 | FDRTS | - |
Mycobacterium tuberculosis |
2.1.1.74 | FDRTS | - |
Clostridium acidi-urici |
2.1.1.74 | FDRTS | - |
Clostridium botulinum |
2.1.1.74 | FDRTS | - |
Rickettsia sp. |
2.1.1.74 | FDRTS | - |
Bacillus anthracis |
2.1.1.74 | FDRTS | - |
Treponema palladium |
2.1.1.74 | folate-dependent ribothymidyl synthase | - |
Geobacillus stearothermophilus |
2.1.1.74 | folate-dependent ribothymidyl synthase | - |
Mycobacterium leprae |
2.1.1.74 | folate-dependent ribothymidyl synthase | - |
Mycobacterium tuberculosis |
2.1.1.74 | folate-dependent ribothymidyl synthase | - |
Clostridium acidi-urici |
2.1.1.74 | folate-dependent ribothymidyl synthase | - |
Clostridium botulinum |
2.1.1.74 | folate-dependent ribothymidyl synthase | - |
Rickettsia sp. |
2.1.1.74 | folate-dependent ribothymidyl synthase | - |
Bacillus anthracis |
2.1.1.74 | folate-dependent ribothymidyl synthase | - |
Treponema palladium |
2.1.1.148 | FDTS | - |
Chlamydia trachomatis |
2.1.1.148 | FDTS | - |
Pyrococcus furiosus |
2.1.1.148 | FDTS | - |
Mycobacterium leprae |
2.1.1.148 | FDTS | - |
Helicobacter pylori |
2.1.1.148 | FDTS | - |
Thermotoga maritima |
2.1.1.148 | FDTS | - |
Clostridium botulinum |
2.1.1.148 | FDTS | - |
Rickettsia sp. |
2.1.1.148 | FDTS | - |
Bacillus anthracis |
2.1.1.148 | FDTS | - |
Paramecium bursaria Chlorella virus-1 |
2.1.1.148 | FDTS | - |
Treponema palladium |
2.1.1.148 | FDTS | - |
Mycobacterium tuberculosis |
2.1.1.148 | flavin-dependent thymidylate synthase | - |
Chlamydia trachomatis |
2.1.1.148 | flavin-dependent thymidylate synthase | - |
Pyrococcus furiosus |
2.1.1.148 | flavin-dependent thymidylate synthase | - |
Mycobacterium leprae |
2.1.1.148 | flavin-dependent thymidylate synthase | - |
Helicobacter pylori |
2.1.1.148 | flavin-dependent thymidylate synthase | - |
Thermotoga maritima |
2.1.1.148 | flavin-dependent thymidylate synthase | - |
Clostridium botulinum |
2.1.1.148 | flavin-dependent thymidylate synthase | - |
Rickettsia sp. |
2.1.1.148 | flavin-dependent thymidylate synthase | - |
Bacillus anthracis |
2.1.1.148 | flavin-dependent thymidylate synthase | - |
Paramecium bursaria Chlorella virus-1 |
2.1.1.148 | flavin-dependent thymidylate synthase | - |
Treponema palladium |
2.1.1.148 | flavin-dependent thymidylate synthase | - |
Mycobacterium tuberculosis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.74 | FADH2 | - |
Geobacillus stearothermophilus | |
2.1.1.74 | FADH2 | - |
Mycobacterium leprae | |
2.1.1.74 | FADH2 | - |
Mycobacterium tuberculosis | |
2.1.1.74 | FADH2 | - |
Clostridium acidi-urici | |
2.1.1.74 | FADH2 | - |
Clostridium botulinum | |
2.1.1.74 | FADH2 | - |
Rickettsia sp. | |
2.1.1.74 | FADH2 | - |
Bacillus anthracis | |
2.1.1.74 | FADH2 | - |
Treponema palladium | |
2.1.1.148 | FAD | - |
Helicobacter pylori | |
2.1.1.148 | NADH | - |
Helicobacter pylori |