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Literature summary extracted from

  • Stolz, M.; Peters-Wendisch, P.; Etterich, H.; Gerharz, T.; Faurie, R.; Sahm, H.; Fersterra, H.; Eggeling, L.
    Reduced folate supply as a key to enhanced L-serine production by Corynebacterium glutamicum (2007), Appl. Environ. Microbiol., 73, 750-755.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.2.1 5,6,7,8-tetrahydrofolate control of SHMT activity by the availability of 5,6,7,8-tetrahydrofolate Corynebacterium glutamicum
2.1.2.1 pyridoxal 5'-phosphate
-
 Corynebacterium glutamicum

Application

EC Number Application Comment Organism
2.1.2.1 pharmacology L-serine is required for pharmaceutical purposes, availability of a sugar-based microbial process for its production is desirable, however, SHMT prevents overproduction of L-serine, control of the essential SHMT activity by a novel physiological approach Corynebacterium glutamicum

Protein Variants

EC Number Protein Variants Comment Organism
2.1.2.1 additional information SHMT activity controlled by Ptac, greatly reduced SHMT activity if no isopropyl-thio-beta-D-galactopyranoside is present, is explicitly prone to chromosomal mutations and rearrangements, thus making the strain unsuitable for large-scale fermentations Corynebacterium glutamicum

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Corynebacterium glutamicum
-
 strain ATCC 13032
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 L-serine + tetrahydrofolate
-
 Corynebacterium glutamicum glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.1 serine hydroxymethyltransferase
-
 Corynebacterium glutamicum
2.1.2.1 SHMT
-
 Corynebacterium glutamicum