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Literature summary extracted from

  • Luescher, A.; Onal, P.; Schweingruber, A.M.; Maeser, P.
    Adenosine kinase of Trypanosoma brucei and its role in susceptibility to adenosine antimetabolites (2007), Antimicrob. Agents Chemother., 51, 3895-3901.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.1.20 analysis the coexpression of adenosine kinase TbAK and adenosine transporter gene TbAT1 in Saccharomyces cerevisiae ado1 ade2 double mutants proves to be a convenient tool for testing nucleoside analogues for uptake and activation by Trypanosoma brucei adenosine salvage enzymes Trypanosoma brucei

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.20 expresion in Saccharomyces cerevisiae Trypanosoma brucei
2.7.1.20 expression of TbAK in Saccharomyces cerevisiae complements a null mutation in the adenosine kinase gene ado1. The concomitant expression of TbAK with the Trypanosoma brucei adenosine transporter gene TbAT1 allows Saccharomyces cerevisiae ado1 ade2 double mutants to grow on adenosine as the sole purine source and, at the same time, sensitizes them to adenosine antimetabolites Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.20 cytosol
-
 Trypanosoma brucei 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.20 additional information Trypanosoma brucei the enzyme plays a role in susceptibility to adenosine antimetabolites ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.20 Trypanosoma brucei
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.20 bloodstream form
-
 Trypanosoma brucei
-
2.7.1.20 procyclic form
-
 Trypanosoma brucei
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.20 additional information the enzyme plays a role in susceptibility to adenosine antimetabolites Trypanosoma brucei ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.20 TbAK
-
 Trypanosoma brucei