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Literature summary extracted from

  • Korycka-Machala, M.; Rychta, E.; Brzostek, A.; Sayer, H.R.; Rumijowska-Galewicz, A.; Bowater, R.P.; Dziadek, J.
    Evaluation of NAD+-dependent DNA ligase of mycobacteria as a potential target for antibiotics (2007), Antimicrob. Agents Chemother., 51, 2888-2897.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
6.5.1.2 medicine although NAD+-dependent DNA ligase is essential for mycobacterial viability, only low levels of protein are required for growth. very efficient inhibition of enzyme activity would be required if NAD+-dependent DNA ligase is to be useful as an antibiotic target in mycobacteria Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.2 NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m Mycolicibacterium smegmatis although NAD+-dependent DNA ligase is essential for mycobacterial viability, only low levels of protein are required for growth AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
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 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.2 Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.2 NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m although NAD+-dependent DNA ligase is essential for mycobacterial viability, only low levels of protein are required for growth Mycolicibacterium smegmatis AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.2 LigA
-
 Mycolicibacterium smegmatis