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Literature summary extracted from

  • Biagini, G.A.; Viriyavejakul, P.; Oneill, P.M.; Bray, P.G.; Ward, S.A.
    Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria (2006), Antimicrob. Agents Chemother., 50, 1841-1851.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 diphenyl iodonium chloride 0.001 mM and above Plasmodium falciparum
7.1.1.2 diphenylene iodonium chloride 0.001 mM and above Plasmodium falciparum
7.1.1.2 additional information insensitive to rotenone Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.1.1.2 0.0051
-
 NADH using decylubiquinone as substrate Plasmodium falciparum
7.1.1.2 0.0167
-
 NADH using ubiquinone-1 as substrate Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
 Plasmodium falciparum 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + decylubiquinone
-
 Plasmodium falciparum NAD+ + decylubiquinol
-
 ?
7.1.1.2 NADH + ubiquinone-1
-
 Plasmodium falciparum NAD+ + ubiquinol-1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 alternative complex I
-
 Plasmodium falciparum
7.1.1.2 alternative NADH oxidoreductase
-
 Plasmodium falciparum
7.1.1.2 NDH2
-
 Plasmodium falciparum
7.1.1.2 type II NADH:dehydrogenase
-
 Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Plasmodium falciparum