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Literature summary extracted from

  • Uchiyama, N.; Kabututu, Z.; Kubata, B.K.; Kiuchi, F.; Ito, M.; Nakajima-Shimada, J.; Aoki, T.; Ohkubo, K.; Fukuzumi, S.; Martin, S.K.; Honda, G.; Urade, Y.
    Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme (2005), Antimicrob. Agents Chemother., 49, 5123-5126.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6.5.5 0.013
-
 nifurtimox
-
 Trypanosoma cruzi
1.6.5.5 0.019
-
 menadione
-
 Trypanosoma cruzi
1.6.5.5 0.03
-
 komaroviquinone
-
 Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.5.5 cytoplasm
-
 Trypanosoma cruzi 5737
-

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.5 Trypanosoma cruzi
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.5 amastigote the enzyme is expressed throughout the Trypanosoma cruzi life cycle Trypanosoma cruzi
-
1.6.5.5 epimastigote the enzyme is expressed throughout the Trypanosoma cruzi life cycle Trypanosoma cruzi
-
1.6.5.5 trypomastigote the enzyme is expressed throughout the Trypanosoma cruzi life cycle Trypanosoma cruzi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.5 NADPH + H+ + komaroviquinone reduction of komaroviquinone to its semiquinone radical. Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme Trypanosoma cruzi NADP+ + ?
-
 ?
1.6.5.5 NADPH + H+ + menadione
-
 Trypanosoma cruzi NADP+ + ?
-
 ?
1.6.5.5 NADPH + H+ + nifurtimox
-
 Trypanosoma cruzi NADP+ + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.5 old yellow enzyme
-
 Trypanosoma cruzi
1.6.5.5 TcOYE
-
 Trypanosoma cruzi

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.5.5 NADPH
-
 Trypanosoma cruzi