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Literature summary extracted from

  • Mellado, E.; Garcia-Effron, G.; Buitrago, M.J.; Alcazar-Fuoli, L.; Cuenca-Estrella, M.; Rodriguez-Tudela, J.L.
    Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility (2005), Antimicrob. Agents Chemother., 49, 2536-2538.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.154 gene cyp51A, DNA and amino acid sequence determination and analysis Aspergillus fumigatus

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.154 additional information gene cyp51A knockout strains CM-A8, CM-A41, and CM-A83 show reduced sensitivity to azole in vivo, overview Aspergillus fumigatus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.154 Amphotericin B
-
 Aspergillus fumigatus
1.14.14.154 fluconazole
-
 Aspergillus fumigatus
1.14.14.154 itraconazole
-
 Aspergillus fumigatus
1.14.14.154 ketoconazole
-
 Aspergillus fumigatus
1.14.14.154 additional information in vivo inhibition study with different strains, overview Aspergillus fumigatus
1.14.14.154 ravuconazole
-
 Aspergillus fumigatus
1.14.14.154 voriconazole
-
 Aspergillus fumigatus

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Aspergillus fumigatus
-
 gene cyp51A, strain CM-237, and azole-insensitive clinical strains CNM-CM-1252 and CNM-CM-796
-

Synonyms

EC Number Synonyms Comment Organism
1.14.14.154 14-alpha sterol demethylase
-
 Aspergillus fumigatus
1.14.14.154 Cyp51A
-
 Aspergillus fumigatus