Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Friedrich, M.; Diesing, D.; Cordes, T.; Fischer, D.; Becker, S.; Chen, T.C.; Flanagan, J.N.; Tangpricha, V.; Gherson, I.; Holick, M.F.; Reichrath, J.
    Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in normal and malignant breast tissue (2006), Anticancer Res., 26, 2615-2620.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.18 clotrimazole in vivo in MCF-7 cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.18 25-hydroxyvitamin D + NADPH + O2 Homo sapiens
-
 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?
1.14.15.18 additional information Homo sapiens the enzyme is involved in local production of 1alpha,25-dihydroxyvitamin D, i.e. 1alpha,25(OH)2D3, in tumorigenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.18 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.18 breast
-
 Homo sapiens
-
1.14.15.18 breast cancer cell
-
 Homo sapiens
-
1.14.15.18 colonic cancer cell
-
 Homo sapiens
-
1.14.15.18 MCF-7 cell
-
 Homo sapiens
-
1.14.15.18 prostate cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.18 25-hydroxyvitamin D + NADPH + O2
-
 Homo sapiens 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?
1.14.15.18 additional information the enzyme is involved in local production of 1alpha,25-dihydroxyvitamin D, i.e. 1alpha,25(OH)2D3, in tumorigenesis Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.18 1alpha-OHase
-
 Homo sapiens
1.14.15.18 extra-renal 25-hydroxyvitamin D3 1alpha-hydroxylase
-
 Homo sapiens
1.14.15.18 [25(OH)D3]-1alpha-hydroxylase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.18 NADPH
-
 Homo sapiens