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Literature summary extracted from

  • Cuvillier, O.
    Sphingosine kinase-1 - a potential therapeutic target in cancer (2007), Anticancer Drugs, 18, 105-110.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.91 medicine potential therapeutic target in anti-cancer therapy Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.91 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole
-
 Homo sapiens
2.7.1.91 B5354c
-
 Homo sapiens
2.7.1.91 camptothecin
-
 Homo sapiens
2.7.1.91 dimethylsphingosine potent competitive inhibitor Homo sapiens
2.7.1.91 DL-threo-dihydrosphingosine potent competitive inhibitor Homo sapiens
2.7.1.91 docetaxel
-
 Homo sapiens
2.7.1.91 F-12509A
-
 Homo sapiens
2.7.1.91 S-12183a
-
 Homo sapiens
2.7.1.91 S-12183b
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Homo sapiens Q9NYA1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 brain
-
 Homo sapiens
-
2.7.1.91 breast
-
 Homo sapiens
-
2.7.1.91 breast cancer cell
-
 Homo sapiens
-
2.7.1.91 cervical carcinoma cell
-
 Homo sapiens
-
2.7.1.91 colon
-
 Homo sapiens
-
2.7.1.91 colonic cancer cell
-
 Homo sapiens
-
2.7.1.91 fibroblast
-
 Homo sapiens
-
2.7.1.91 gastric cancer cell
-
 Homo sapiens
-
2.7.1.91 hepatoma cell
-
 Homo sapiens
-
2.7.1.91 kidney
-
 Homo sapiens
-
2.7.1.91 leukemia cell
-
 Homo sapiens
-
2.7.1.91 lung
-
 Homo sapiens
-
2.7.1.91 lung cancer cell
-
 Homo sapiens
-
2.7.1.91 MCF-7 cell
-
 Homo sapiens
-
2.7.1.91 melanoma cell
-
 Homo sapiens
-
2.7.1.91 neuroblastoma cell
-
 Homo sapiens
-
2.7.1.91 ovary
-
 Homo sapiens
-
2.7.1.91 pancreatic cancer cell
-
 Homo sapiens
-
2.7.1.91 prostate adenocarcinoma cell
-
 Homo sapiens
-
2.7.1.91 rectum
-
 Homo sapiens
-
2.7.1.91 small intestine
-
 Homo sapiens
-
2.7.1.91 stomach
-
 Homo sapiens
-
2.7.1.91 uterus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.91 ATP + sphingosine
-
 Homo sapiens ADP + sphingosine 1-phosphate
-
 ir

Synonyms

EC Number Synonyms Comment Organism
2.7.1.91 sphingosine kinase-1
-
 Homo sapiens
2.7.1.91 SPHK1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.91 ATP
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.91 0.0037
-
 B5354c
-
 Homo sapiens
2.7.1.91 0.004
-
 F-12509A
-
 Homo sapiens
2.7.1.91 0.005
-
 dimethylsphingosine
-
 Homo sapiens
2.7.1.91 0.01
-
 DL-threo-dihydrosphingosine
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.91 0.0005
-
-
 Homo sapiens 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole
2.7.1.91 0.0016
-
-
 Homo sapiens S-12183b
2.7.1.91 0.0025
-
-
 Homo sapiens S-12183a