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Literature summary extracted from

  • Calderon-Cortes, E.; Clemente-Guerrero, M.; Sierra-Campos, E.; Cortes-Rojo, C.; Gaona-Zamudio, F.J.; Villalobos-Molina, R.; Saavedra-Molina, A.
    Functional characterization of brain mitochondrial nitric oxide synthase during hypertension and aging (2006), Amino Acids, 30, 73-80.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.39 7-nitroindazole
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.39 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Rattus norvegicus mitochondrial nitric oxide production is involved in modulation of several organelle functions, such as transmembrane potential and matrix pH, inhibition of respiration by competitive inhibition with oxygen in cytochrome c oxidase, inhibition of ATP synthesis, permeability transition pore (PTP) opening, apoptosis and cell death, overview 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.39 Rattus norvegicus
-
 Wistar and Wistar-Kyoto rats, and 1 month-old, prehypertensive/spontaneously hypertensive rats
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.13.39 partially by mitochondria preparation Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.39 brain
-
 Rattus norvegicus
-
1.14.13.39 heart
-
 Rattus norvegicus
-
1.14.13.39 kidney
-
 Rattus norvegicus
-
1.14.13.39 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.13.39 additional information
-
 activity in hypertensive and healthy rats, overview Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ mitochondrial nitric oxide production is involved in modulation of several organelle functions, such as transmembrane potential and matrix pH, inhibition of respiration by competitive inhibition with oxygen in cytochrome c oxidase, inhibition of ATP synthesis, permeability transition pore (PTP) opening, apoptosis and cell death, overview Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.39 mtNOS
-
 Rattus norvegicus
1.14.13.39 nitric oxide synthase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.13.39 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.13.39 7.4
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.39 NADPH
-
 Rattus norvegicus