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Literature summary extracted from

  • Auliff, A.; Wilson, D.W.; Russell, B.; Gao, Q.; Chen, N.; Anh le, N.; Maguire, J.; Bell, D.; O'Neil, M.T.; Cheng, Q.
    Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugs (2006), Am. J. Trop. Med. Hyg., 75, 617-621.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.15 additional information assessment of mutations in DHPS associated with antifolate resistance in several geographical regions Plasmodium vivax

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.15 cycloguanil
-
 Plasmodium vivax
2.5.1.15 pyrimethamine
-
 Plasmodium vivax
2.5.1.15 WR99210
-
 Plasmodium vivax

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate Plasmodium vivax
-
 diphosphate + 7,8-dihydropteroate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.15 Plasmodium vivax Q00LY0 fragment of dihydropteroate synthase
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.15 bloodstream form
-
 Plasmodium vivax
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
 Plasmodium vivax diphosphate + 7,8-dihydropteroate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.15 7,8-dihydropteroate synthase
-
 Plasmodium vivax
2.5.1.15 DHPS
-
 Plasmodium vivax
2.5.1.15 dihydropteroate synthetase
-
 Plasmodium vivax
2.5.1.15 pvdhps
-
 Plasmodium vivax