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Literature summary extracted from

  • Banday, A.A.; Fazili, F.R.; Lokhandwala, M.F.
    Insulin causes renal dopamine D1 receptor desensitization via GRK2-mediated receptor phosphorylation involving phosphatidylinositol 3-kinase and protein kinase C (2007), Am. J. Physiol. Renal Physiol., 293, F877-F884.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.15 Insulin leads to increase dopamine D1 receptor serine phosphorylation by GRK2 Didelphis virginiana

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.15 additional information expression of GRK2-specific siRNA leads to downregulation of the enzyme Didelphis virginiana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.15 membrane insulin causes GRK2 translocation to the membranes, which is blocked by genistein, wortmannin, chelerythrine chloride, and GRK2-specific siRNA Didelphis virginiana 16020
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Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.15 Mg2+
-
 Didelphis virginiana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 ATP + dopamine D1 receptor Didelphis virginiana phosphorylation by GRK2 has a regulatory role as part of the PI3K-PKC-GRK2 cascade ADP + phosphorylated dopamine D1 receptor
-
 ?
2.7.11.15 additional information Didelphis virginiana insulin-mediated dopamine D1 receptor desensitization and underlying molecular mechanism in opossum kidney cells, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Didelphis virginiana O97627 North American opossum, gene GRK2
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.15 cell culture
-
 Didelphis virginiana
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2.7.11.15 kidney
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 Didelphis virginiana
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2.7.11.15 OK cell a renal proximal tubular cell line Didelphis virginiana
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 ATP + dopamine D1 receptor phosphorylation by GRK2 has a regulatory role as part of the PI3K-PKC-GRK2 cascade Didelphis virginiana ADP + phosphorylated dopamine D1 receptor
-
 ?
2.7.11.15 ATP + dopamine D1 receptor hyperserine phosphorylation by GRK2 Didelphis virginiana ADP + phosphorylated dopamine D1 receptor
-
 ?
2.7.11.15 additional information insulin-mediated dopamine D1 receptor desensitization and underlying molecular mechanism in opossum kidney cells, overview Didelphis virginiana ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.15 G protein-coupled receptor kinase 2
-
 Didelphis virginiana
2.7.11.15 GRK2
-
 Didelphis virginiana

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.15 ATP
-
 Didelphis virginiana