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Literature summary extracted from

  • Levillain, O.; Ventura, G.; Dechaud, H.; Hobeika, M.; Meseguer, A.; Moinard, C.; Cynober, L.
    Sex-differential expression of ornithine aminotransferase in the mouse kidney (2007), Am. J. Physiol. Renal Physiol., 292, F1016-F1027.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.6.1.13 medicine before puberty, ornithine aminotransferase expression is similar between female and male kidneys whereas from puberty until adulthood ornithine aminotransferase expression increases in the female kidney, becoming 2.5fold higher than in the male kidney. This sex-differential expression of ornithine aminotransferase is associated with a sex-specific distribution of enzyme along the corticopapillary axis and within the nephron. Ornithine aminotransferase is three- to fourfold more expressed in the female than the male cortex. In males, enzyme is highly expressed in the medulla, mainly in the thick ascending limbs. Renal enzyme distribution in orchidectomized mice resembles that in the females. Ovariectomy does not influence enzyme expression. Ornithine aminotransferase is naturally downregulated in the presence of testosterone Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.13 testosterone ornithine aminotransferase is naturally downregulated in the presence of testosterone Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.13 mitochondrion
-
 Mus musculus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.13 48000
-
 SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.13 Mus musculus P29758
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.13 kidney
-
 Mus musculus
-
2.6.1.13 kidney before puberty, ornithine aminotransferase expression is similar between female and male kidneys whereas from puberty until adulthood ornithine aminotransferase expression increases in the female kidney, becoming 2.5fold higher than in the male kidney. This sex-differential expression of ornithine aminotransferase is associated with a sex-specific distribution of enzyme along the corticopapillary axis and within the nephron. Ornithine aminotransferase is three- to fourfold more expressed in the female than the male cortex. In males, enzyme is highly expressed in the medulla, mainly in the thick ascending limbs. Renal enzyme distribution in orchidectomized mice resembles that in the females. Ovariectomy does not influence enzyme expression. Ornithine aminotransferase is naturally downregulated in the presence of testosterone Mus musculus
-
2.6.1.13 renal cortex highest expression in female mice Mus musculus
-
2.6.1.13 renal medulla highest expression in male mice Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.13 L-ornithine + 2-oxoglutarate
-
 Mus musculus DELTA1-pyrroline-5-carboxylate + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.13 OAT
-
 Mus musculus
2.6.1.13 ornithine aminotransferase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.13 pyridoxal 5'-phosphate
-
 Mus musculus